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Study of Tumor with Frontal Lobe by the Fractional Amplitude of Low Frequency Fluctuation of Resting-state Functional Magnetic Resonance Imaging

ZHAO Cuihua;TAO Ling;YU Zhou;WU Jiangfen;SUN Jinyang;ZHOU Hui;School of Automation,Nanjing University of Aeronautics & Astronautics;  
To investigate pathological mechanism of dysfunction of cognitive control in tumor in frontal lobe,using a resting- state functional magnetic resonance imaging( f MRI) index,fractional amplitude of low frequency fluctuation( f ALFF). 14 patients with tumor in frontal lobe and 14 gender,age and education- matched healthy controls were experienced resting- state f MRI scans. f ALFF approach was used to analyze f MRI data in resting state. Compared with healthy control group,the group with frontal lobe tumor showed the increased value of f ALFF in the right orbitofrontal,right temporal lobe,right supplementary motor area,left parahippocampal gyrus,left posterior cingulate gyrus,the left medial cingulate and paracentral lobule,in the bilateral dorsolateral frontal gyrus,bilateral medial frontal gyrus and Cerebelum. The results show the decreased functional activity in the frontal area of the resting state in the patient' s tumor in frontal lobe,which is part of the frontal lobe tissue of the inactivation of tumor,whereas the rest of the default mode network regions and the enhancements of supplementary motor area may be related to cognitive dysfunction and compensatory effect.
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