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Synergism and Attenuation Effects of Scapharca Subcrenata Extraction on Cyclophosphamide

FENG Qiaoqiao;LIU Juntian;MA Yukui;Center for Drug Evaluation and Certification of Shandong Food and Drug Administration;Shandong Pharmaceutical Academy;  
To investigate the synergism and attenuation effects of Scapharca Subcrenata Extraction on cyclophosphamide in model mice. The models of mouse were induced with S180 tumor and cyclophosphamide. The tumor inhibiting rates,white blood cell number,giant cell phagocytosis,hemolysin level and indexes of thymus and spleen were determined to evaluate the synergism and attenuation effects of Scapharca Subcrenata Extraction on cyclophosphamide. Compared with cyclophosphamide group,the tumor inhibiting rates,white blood cell number,giant cell phagocytosis,hemolysin level and indexes of thymus and spleen were increased markedly in cyclophosphamide plus Scapharca Subcrenata Extraction groups. Scapharca Subcrenata Extraction has a remarkable synergism and attenuation effects on cyclophosphamide through its immune adjustment function.
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