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《Shandong Medical Journal》 2002-02
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The protective efects of carboxyethyi-germanium squioxide on lung ischeia-reperfusion injury in rats

He Qi,Wang Yang,Wang Shanzheng  
In order to observe the effects of carboxyethyl-germandium sesquioxide(CGS)on lung ischemia-reperfusion,the experimental model was established by ligaturing left lung hilum for 30 minutes followed by reperfusing for 60 minutes in the rats The left pulmonary artery pressure,left lung Mw/Md,level of MDA,activity of SOD and ATPase were measured The results showed after CGS (50mg/kg) was intravenous injected,the level of MDA decreased, activity of SOD and ATPase in lung of rats were increased respectively (F=6 37,q=8 98,P0 01;F=3 85,q=4,21,P0 05;F=4 06,q=5,38,P0 001;F=6 37,q=10 21,P0 001;F=6 37,q=8,64,P0 05) This suggest that CGS might have a protective effect on the damage of lung ischemia-reperfusion in rats
【CateGory Index】: R655.3
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【Citations】
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【Co-citations】
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