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C-myc Oncogene Overexpression in Endometrial Cancers and Its Clinicopathological Characteristics.

LAI Dongmei,ZHU Guanzhen,ZHOU Jianping,et al (Zhongshan Hospital,Shanghai Medical University,Shanghai 200032)  
Objectives: To study the overexpression of c myc in endometrial carcinoma and its relationship to clinicopathological features and prognosis.Methods:Overexpression of c myc was studied by immunohistochemistry ABC method in paraffin-embedded tissues in 49 endometrial carcinoma and 25 normal or hyperplasia endometrium.χ 2 analysis and survival curves determined by the Kaplan-Meier method were used.Results:c-myc overexpression was negative in normal or hyperplasia endometrium,but positive in 20 percent endometrial carcinoma.c-myc overexpression was found to be correlation with FIGO G 1,G 2 and G 3,but not with muscle invasion,stages or survival.Conclusion:c-myc oncogen may play a role in the formation,not in the development of endometrial carcinoma.
【CateGory Index】: R737.33
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