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《Journal of Shanghai Normal University(Natural Sciences)》 2011-01
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Synthesis,crystal structure and bioactivity of 1-(4-Methylbenzyl)piperidin-4-one O-(6-chloropyridin-3-yl)methyl oxime

MA Xu-bo,YIN An-qin,XUE Si-jia(College of Life and Environment Sciences,Shanghai Normal University,Shanghai 200234,China)  
A novel 1-(4-Methylbenzyl)piperidin-4-one O-(6-chloropyridin-3-yl)methyl oxime compound was synthesized by the reaction of 1-(4-methylbenzyl)piperidin-4-one oxime with 2-chloro-5-chloromethylpyridine,followed by characterization with elemental analysis,IR,1 H NMR spectra and single-crystal X-ray diffraction.The crystal belongs to the monoclinic system,space group P 2(1) with a =9.486(6),b =6.317(4),c =15.027(10),α =90,β =93.178(8),γ =90°,V =899.0(10) 3,Z =2,Dc = 1.270 g/cm 3,μ =0.223 mm-1,M r =343.85,F(000)=364,S =1.019,the final R =0.0732 and wR =0.1902.The molecule was nonplanar,the piperidine exhibited a chair conformation.The dihedral angle made by the pyridine ring with the benzene ring was 86.1(9)°.No intra-or intermolecular hydrogen bonds were identified in the crystal structure.Bioassays indicated that the as-prepared compound exhibited broad inhibitory activities toward fungi at the concentration of 1×10-4.
【Fund】: reported by the Shanghai Key Laboratory of Thulium Functional Materials(O7D222303)
【CateGory Index】: O626.32
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