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《Journal of Shanghai Normal University(Natural Sciences)》 2011-01
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Antioxidant effects of Injection Stauntoniae on the oxidative damaged cortical neurons

ZHOU Li-na,YE Wen-bo (College of Life and Environment Sciences,Shanghai Normal University,Shanghai 200234,China)  
Objective to study the neuroprotective effects of Injection Stauntoniae(IS) on the cultured and oxidative damaged cortical neurons.Methods Mice primary cortical neurons were exposed to 100 μmol/L H 2O 2.The morphological changes of cortical neurons were observed via the inverted microscope.Measurement of the release of LDH,SOD activity,and the MTT assay were performed to test effects of IS on cortical neurons,in addition to the α-deoxyribose oxidation assay that was used to elucidate the hydroxyl radical-scavenging activity of IS.Results IS(25-300 mg/L)could protect neurons from oxidative injury,increase the activity of SOD and decrease the release of LDH,with the optimal concentration at 100 mg/L.Compared with positive control(Mannitol),IS could scavenge more hydroxyl radicals.Conclusion IS had stronger antioxidant activity and could protect neurons from H 2O 2-induced oxidative injury effectively.
【Fund】: 上海师范大学科研项目(SK200715)
【CateGory Index】: R285.5
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