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《》 1993-01
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EXPERIMENTAL PARKINSON'S DISEASE AND ITS IMMUNOLOGICAL STATE

Li Kangsheng Yu Xiukui Yang Mianhua Liu TiefuDepartment of Microbiology, Shantou University Medical College(Shantou, Guangdong, 515031)  
An experimental Parkinson's Disease (PD)model was established in Wistar rats by electric destruction of Substantia Nigra (SN). Four days after the destruction, immu- nological status examination of the rats revealed: depressed thymocyte spontaneous proliferation (p0.05), increased antibody production to SEBC by splenocytes (p 0.05), enhanced cytotoxicity of natural killer cells (NK) in spleen (p0.05) but no obvious change in thymocyte and splenocyte proliferation induced by ConA. Dopamine was not found to have direct effects on immune cells in vitro.
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