MEASUREMENT OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR IN CONNECTIVE TISSUE DISEASES
Cai Hou-rong,et al. Department of Internal Medicine,The Affiliated Gu-lou Hospital of Nanjin University School of Medicine, Nanjin City,China,210008
Serum soluble interleukin-2 receptor (sIL-2R) levels in patients with connective tissue disease (CTD) were measured by sandwiched ELISA. The concentrations of sIL-2R in patients with mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE) and rheumatic arthritis (RA) were higher than those in normal controls. During treatment, it was found that the sIL-2R concentrations fell when the disease became controlled. The results suggested that there were lymphocyte activations in patients with CTD. The measurement of sIL-2R concentrations might help to monitor the disease activity and served as a meaningful parameter reflecting cellular immunity in human body.