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STUDY ON CROSS-REACTIVITY AMONG HISTONE, CAMPYLOBACTER jE JUNI AND ENA

Cao Henian. Ma Baoli Wang Zhenhe Zang Xingxing Wang Li Bai JimDepartment of Basic Immunology,Shanghai Institute of Immunology, Department of Immunology,Shanghai Second Medical University, Shanghai 200025  
Using 3 different monoclonal antibodies(McAbs)with cross-reactivity between cam-pylobacter jejuni and extracted nuclear antigen (ENA), We demostrated with ELISA and competitive inhibition test that one of these 3 McAbs could bind to histone with enzyme index(EI) of 343 and competitive inhibitory ratio of 35%, suggesting that the comformational molecular mimicry among histone, ENA and membrane protein of campylobacter jejuni might play an important role in campylobacter jejuni induced autoimmune syndrome. With animal model of autoimmune syndrome it waa shown that the detection of anti-histone antibody could have diagnostic value in early stage of autoimmune diseases.
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