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DECREASE IN IL-4 PRODUCING CELLS IN PLASMA CELL DYSCRASIAS: ITS SIGNIFICANCE AND POSSIBLE MECHANISM

Hou Jian Wang Li Liu Yan Kong Xiantao Wang Yulian Chang Zheng Hospital, The Second Military Medical University,Shanghai,200003  
In this paper, the capability of peripheral blood cells to produce IL-4 under the stimulation of PHA in 15 healthy controls and 16 patients with plasma cell dyscrasias was detected by APAAP method. It was found that positive cells were significantly less in patients than these in normal controls (P0.001) (positively correlated to the serum polyclonal IgA and IgM concentrations). We also found that the patients' serum CRP concentrations were higher than those in normal controls (P0.001). Adding 50mg/L CRP in the culture of normal peripheral blood made the IL-4 producing cells decrease greatly (P0.001). The authors hypothesized that suppression of IL-4 production by increase in CRP and other acute phase proteins due to higher serum IL-6 activities in plasma cell dycrasias would result in defective activation of B cells, leading to decrease in synthesis of polyclonal immunoglobulins.
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【References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Yin-xia, LIU Jie, MA Xiao-rong, YANG Yun, ZHANG Wang-gang, HE Ai-li, TIAN Wei Department of Hematology, Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004,China;Assay of lymphocyte subsets in patients with multiple myeloma and its significance[J];Journal of Modern Oncology;2006-11
2 LU Ming,ZHOU Xiaoqing.and KONG Xiantao. Department of Hematdogy, Shanghai Municipal Corps Hospital, Chinese People's Armed Police Forces,Shanghai 201103, China;Analysis of T lymphocyte subset and B lymphocyte - related imtnunotypes in peripheral Mood of patients with multiple myeloma[J];Medical Journal of the Chinese People's Armed Police Forces;2003-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Lü Ming, Kong Xiantao, Huang Longan. Changzheng Hospital, the Second Military Medical University, Shanghai 200003;DETECTION OF PERIPHERAL BLOOD TUMOR RELATED B LYMPHOCYTE IN MULTIPLE MYELOMA BY SEMINESTED PCR[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1997-04
2 Chen Yubao, Hou Jian, Huang Longan, Ding Siqi, Yu Runquan(Department of Haematology, Changzheng Hospital, Second Military Medical University, Shanghai 200003);EFFECT OF INTERLEUKIN-6 ON EXPRESSION OF COLLAGENASE TYPE 1 mRNA IN ISOLATED RABBIT OSTEOCLAST IN VITRO[J];Chinese Journal of Anatomy;1998-02
3 Hou Jian,Kong Xiantao (.Chang Zheng Hospital,The Second Military Medical University,Shanghai ?200003) Zhang Hejun (Laboratory of Immunology, Medical Biology Institute of the Academy of Medical Sciences of China, Kunming 650107);Regulation of the Proliferation of Human Myeloma Cell Line,KM_3, by Recombinant IL-4 and IFN_γ[J];Immunological Journal;1993-02
4 SUN Jiang-Fei, LOU Yan-Ru, MU Qi-Tian, et al.(Ningbo No.1 Hospital,Ni ngbo 315010, China);Immunophenotype analysis of 32 patients with mutiple myeloma[J];Modern Practical Medicine;2005-01
5 Hou Jian Kong Xiantao Xie Yinhua Chen Xin Liu Yan Chang Zheng Hospital, The Second Military Mdeical University.;CORRELATIONS BETWEEN SERUM INTERLEUKIN 6 ACTIVITIES AND ACUTE PHASE PROTEIN CONCENTRATIONS IN MULTIPLE MYELOMA[J];;1993-02
6 Hou Jian,Ding Siqi,Li Yanhong.et al. (Chang Zheng Hospital,2nd Military Medical University);Influences of IL-6 on mRNA Expression of Type I Procollagen and Type I Collagenase in Rat Osteoblasts[J];Shanghai J.of Immunology;1998-02
7 Hou Jian, Zhao Yaping, Liu Yan, et al. * Changzheng Hospital, The Second Military Medical University, Shanghai 200003;CLINICAL SIGNIFICANCE OF DETERMINING SERUM SOLUBLE IL 6 RECEPTOR CONCENTRATION IN PLASMA CELL DYSCRASIAS[J];CHINESE JOURNAL OF INTERNAL MEDICINE;1997-02
8 Cao Xuetal; Yu Yizhi; Xu Zhigong ;et al Department of Immunology,Second Military Medical University,Shanghai 200433 B16 melanoma cells were transfected with murine IL-4 gene and the cell clone secreting highest level of IL-4was selected.The experimental p;TRE ATMENT OF PULMONARY METASTATIC MELANOMA WITH CELLULAR VACCINE GENETICALLYENGINEERED TO SECRET INTERLEUKIN-4 AND ITS IMMUNOLOGICAL MECHANISMS[J];Chinese Journal of Microbiology and Immunology;1995-01
9 Qian Qifeng Shenzhen Institute of Di-rmatuluy of Dermatology,Shenzhen 518003;STUDY ON THE RELATIONSHIP BETWEEN SERUM IL-4 AND IgE IN PATIENTS WITH ATOPIC DERMATITIS[J];Chinese Journal of Microbiology and Immunology;1995-05
10 Hou Jian and Kong Xian-tao(Institute of Clinical Immunology ,Chang Zheng Hospital, The Second Military Medical University Shang hai 200003);EFFECTS OF INTERLEUKIN 4 ON THE PHENOTYPES RELATED TO ANTIBODY PRODUCTON OF PERIPHERAL BLOOD CELLS IN PATIENTS WITH MULTIPLE MYELOMA[J];CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY;1994-02
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