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《上海免疫学杂志》 1993-05
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DETECTION AND CLINICAL SIGNIFICANCE OF HEPATITIS C VIRUS INFECTION-ASSOCIATED AUTOANTIBODY (ANTI-GOR)

Zhang Yan Lu Zhimeng Wang ShihuangDepartment of Infectious Disease, Ruijin Hospital, Shanghai SecondMedical University, Shanghai 200025Lin Xiaohong Cui Dafu Biochemistry Institute, Academy of Chinese Sciences,Shanghai 200031  
We synthesized a peptids GOR as antigen for detection of HCV infection-associated autoimmune antibody with ELISA. 581 serum samples from various clinical groups were tested for anti-GOR and the antibodies were detected in 19.2% patients with acute NANBH, 25.7% with chronic NANBH but in less than 10% patients with HA,HB and SLE,etc. The positive rate of anti-GOR in NANBH was lower than that of anti-HCV, but they were complementary to each other. The antibody to GOR was well related to the HCV core antibody. The results showed:(1).Antibody to GOR was related to HCV infection. (2). Detecting both anti-GOR and anti-HCV at the same time, we could improve the diagnosis rate of HCV infection. (3). HCV infection was possibly due to the combination of HCV core protein with host protein, inducing the host to produce the auto-antibody (anti-GOR).
【Fund】: 国家自然科学基金
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIU Wenen ; TAN Deming; ZHANG Zheng et al .( Department of Infections Diseases, Xiangya Hospital , Hunan Medical University , Changsha 4 10008, China)[;Lymphocyte subset and its apoptosis in chronic hepatitis C[J];中华肝脏病杂志;2000-05
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Zhang Yan Lu Zhimeng Wang ShihuangDepartment of Infectious Disease, Ruijin Hospital, Shanghai SecondMedical University, Shanghai 200025Lin Xiaohong Cui Dafu Biochemistry Institute, Academy of Chinese Sciences,Shanghai 200031;DETECTION AND CLINICAL SIGNIFICANCE OF HEPATITIS C VIRUS INFECTION-ASSOCIATED AUTOANTIBODY (ANTI-GOR)[J];上海免疫学杂志;1993-05
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