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《Shanghai J.of Immunology》 1997-01
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Study on the Pokeweed Mitogen Dependent Murine Peritoneal Elicited Macrophage(PEMf) Mediated Cytotoxicity

Wang Xiao, Dong Haidong, Xing Rong, Guo Lianying, Qian Zhenchao (Department of pathophysio-logy, Dalian Medical University, Dalian 116023)  
In this paper, indirect MTT assay was used in detecting PDMC(PWM de-pendent macrophage mediated cytotoxicity). The results indicated that the cytotoxic effect of lectin (PWM, ConA) pretreated target cell(Raji, U14) varied with the kind of lectin and type of target cell; In the assay in which lectin pretreated effector cell or target cell seperately, the lectin pretreated target cell was found to play some key role in lectin depandent Mφ mediated cytotoxicity which could be enhanced further by the direct action of lectin; while the latter may be inhibited by GlcNAc efficient-ly.It was also found that upon PDMC, Raji cells showed some morphological cha-nges in which necrosis and apoptosis did exist simutaneously.
【Fund】: 国家“八五”攻关专题(85-914-02-08)之组成部分 并受国家自然科学基金(39300157)的资助
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 2 Hits
1 WANG Xiao-bo,SONG Zhen-lan (Department of Hematology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027, China);Cytotoxicity of cord blood monocyte-macrophage activated by cytokines against K562 cell line[J];Journal of Dalian Medical University;2003-02
2 DONG Xue-Bin SONG Zhen-Lan (Department of Hematology, Second School of Clinical Medicine, Dalian Medical University Dalian 116023);Cytotoxic effect of PWM and IL-2 activated monocytes against human leukemia[J];Journal of Experimental Hematology;1998-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Dong Haidong, Qian Zhenchao (Dalian Medical University, Dalian, 116023);Studies on the Mechanisms of the Apoptotic Cell Death of Target Cells Mediated by Human Monocytes[J];Chinese Journal of Cancer Biotherapy;1994-01
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 Dong Haidong Qian ZhenchaoDept. of Pathophysiology Dalian Medical College (Dalian 116023);IN VITRO AND IN VIVO ANTITUMOR ACTIVITY OF rTNF AND rIL-2 ACTIVATED MACROPHAGES (CAM)[J];;1991-05
2 DONG Xue-Bin SONG Zhen-Lan (Department of Hematology, Second School of Clinical Medicine, Dalian Medical University Dalian 116023);Cytotoxic effect of PWM and IL-2 activated monocytes against human leukemia[J];Journal of Experimental Hematology;1998-03
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 WANG Xiao-bo,SONG Zhen-lan (Department of Hematology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027, China);Cytotoxicity of cord blood monocyte-macrophage activated by cytokines against K562 cell line[J];Journal of Dalian Medical University;2003-02
2 Zeng Qiyan Zhou Deyi (Guangxi Medical Univ.,6 Binghulu, Nanning, Guangxi,530021,China);Structure Analysis of Oligosaccharide Link and Summaries of Clinical Applications in Leptins[J];Guangxi Sciences;2001-02
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