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《Shanghai J.of Immunology》 1997-01
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The Study on the Association Between the Hypertrophic Cardiomyopathy and HLA-DQ

Zhang Xiuwu, Zhang Zhijiong, Guo Xun, Guo Zhaogui (Department of Molecular Pharmacology, Hunan Medical University, Changsha, 410078)  
Using PCR/SSO technique, we analyzed DQA1 and DQB1 polymorphisms in 41 patients with hypertrophic cardiomyopathy and 52 healthy HANs. The results showed that the alleles frequencies of DQAl * 0201, DQB1 * 0502, 0504 were signifi-cantly lower in hypertrophic cardiomyopathy patients as compared with those in the normal controls with a relative risk value of 9.51, 5.87 and 11.60 respectively; While the alleles frequencies of DQAl * 0501, DQB1 * 03031 were considerably increased in hypertrophic cardiomyopathy patients as compared with those in the normal controls with a relative risk value of 2.93 and 6.65 respectively, These results suggested that hypertrophic cardiomyopathy is associated with HLA-DQ gene.
【Fund】: 国家自然科学基金资助项目NO:39370310
【CateGory Index】: R542.2
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