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B Lymphocyte Function in Chronic Hepatitis B Patients

Shan Meimei, Lu Ping, Yao Guangbi (Clinical Immunology Research Center, Jingan Qu Central Hospital, Shanghai 200040)  
B lymphocyte functions were studied in 24 patients with chronic hepatitis B. Among them, seven patients were CPH and 17 were CAH. The serum IgG and IgM levels were markedly elevated in CAH patients and were normal in CPH pa-tients. Peripheral mononuclear cells were incubated with PWM(Pokeweed Mitogen) in vitro, IgG, IgM in supernatant and 3H-TdR incorporation were assayed. The spontaneous production of IgG in CAHs was significantly elevated, whereas was normal in CPH. After stimulated with PWM, the production of IgG and 3H-TdR in-corporation were reduced in CAH patients as compared with controls. The produc-tion of IgG and 3H-TdR corporation were both increased after PWM stimulation in CPH patients. The serum IgG levels were correlated with the spontaneous produc-tion of IgG in vitro. It is therefore suggested that B cell function is suppressed in chronic active B hepatitis patients.
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