The Role of T Lymphocytes in Allergic Asthma
Wu Changgui, Sun Bin and Mi Jianxin (Dept. of Respiratory Disease, Xi Jing Hospital, the 4th Mi-litary Medical University, Xian 710032)
In order to inquire the role of T-lymphocytes in the paroxysms of allergic asthma, T-cell subsets and their activation status were evaluated in 20 allergic as-thmatics during acute attacks by immunocytochemistry using APAAP method. Com-paring those with 20 remissive cases and 20 healthy controls, we found that the per-centages of positive CD25 T-cell and HLA-DR T-cell, which were activated, were higher in the cases of episodes than those in other two groups (P0.01). No dif-ference was observed between the patients without symptoms and the normal indiv-iduals. CD4 +T-cells, HLA-DR+ T-cells, and CD4/CD8 ratio showed no difference ei-ther among the three groups. Significant correlations were found between number of CD25+ T-cells or HLA-DR + T-cells and serum total level of IgE (r = 0.3855, 0.3554, respectively, P0.05), or FEVl(r=-0.6884, -0.5874, respectively, P0.01) in the symptomatic asthmatics. The results suggested that activated CD4 T-cells may play an important role in the pathogenisis of allergic asthma.
【CateGory Index】： R562.25