Suppressive Effects of Ketotifen Fumarate on Proliferative Responses of Lymphocytes in Patients with Food Sensitive Atopic Dermatitis
Geng Paili, Naomi Kondo* (Department of Microbiology & Immunology, Qinghai Medical College,Xining, Qinghai 810001; * Gifu University School of Medicine,Gifu, Japan)
In this study, the proliferative responses of peripheral blood mononuclear cells (PBMCs) to oval-bumin (OA) in children with atopic dermatitis (AD), who are sensitive to hen's egg, were significantly higher than those of healthy children. The proliferative responses of PBMCs to OA were dose-dependently inhibited by ketotifen and this inhibition was realized by the effects of ketotifen on T cells. In contrast, the proliferative responses of PBMCs to phytohemagglutinin and tetanus toxoid were not inhibited by ketotifen. These results suggest that ketotifen only inbibits food antigen-specific proliferative responses of PBMCs in patients with food sensitive AD.
【CateGory Index】： R758.2