Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Shanghai J.of Immunology》 1997-04
Add to Favorite Get Latest Update

HLA-DQ Polymorphism and Susceptibility to Systemic Lupus Erythematosus

Peng Xuebiao, Fei Hongming, Yue Xiaoyu,et al(Department of Dermatology,Nanfang Hos-pital, The First Military Medical University, Guangzhou 510515; Department of Biology, Shanghai Second Medical Univesity Shanghai 200025)  
We used polymerase chain reaction (PCR) and digoxigenin-labeled sequence specific oligonu-cleotide (SSO) probe hybridization to type HLA-DQ subregion in patients of Han nationality with systemic lupus erythematosus(SLE) and matched control subjects. The results showed that DQA1 * 0102 gene frequency (RR=3. 43,Pc = 0. 03164) and HLA-DQA1 * 0102,DQB1 * 0601 (RR = 9. 4,Rc = 0. 027) and HLA-DQA1 * 0102,DQB1 * 0602(RR = 12. 4,Pc = 0. 007)haplotype frequecies were significantly higher than those of controls, whereas DQA1 * 0601 was significantly lower in patients, compared with controls (RR = 0. 29,Pc = 0. 04612),but there was no relation between DQB1 allelels and SLE. It suggests that DQA1 * 0102 may be a susceptibile gene of the patients with SLE,and DQAl * 0601 may have a protective effect.
【CateGory Index】: R593.241
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 PAN Zheng-lun, ZHANG Yuan-chao, SUN Hong-sheng. Department of Rheumatology, Shandong Provincial Hospital, Shangdong University, Jinan 250021, China;Meta-analysis of the association between systemic lupus erythematosus with HLA-DQA1 in the Han nationality of Chinese in the mailand of China[J];Chinese Journal of Rheumatology;2006-02
2 Xu Jinrui Yang Yi Zhang Dongtao et al Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China,Ningxia University(Yinchuan 750021);The study of polymorphisms of HLA-DQA_1 in Ningxia Hui and Han population[J];Shaanxi Medical Journal;2009-09
3 CAO Xiu-jing,YE Dong-qing,LI Xiang-pei,et al (Department of Epidemiology Anhui Medical University,Hefei 230032,China);Study on the Association of HLA-DQA1 Alleles and Systemic Lupus Erythematosus in Anhui Hans Chinese[J];The Chinese Journal of Dermatovenereology;2004-02
4 CHEN Shang wuSchool of Life Sciences,Zhongshan University,Guangzhou 510275,China,FENG Bing jian,PAN De jing,CHEN Rong xiang, XU An long;Computer Analysis of Human HLA DQ Locus Polymorphism and Genotyping by PCR RFLP[J];ACTA SCIENTIARUM NATURALIUM UNIVERSITATIS SUNYATSENI;1999-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 PAN Zheng-lun, ZHANG Yuan-chao. Department of Rheumatology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China;Meta-analysis of the association between rheumatoid arthritis with HLA-DRB1 in China[J];Chinese Journal of Rheumatology;2004-11
2 Peng Xuebiao; Xu Wengyan; Yue Xiaoyu; et al.(Institute of Dermatology, Chinese Academy of Medical Science. Peking Union Medical College);Allelic polymorphism analysis of HLA-DQA1 in Han's patients with systemic lupus erythematosus[J];JOURNAL OF CLINICAL DERMATOLOGY;1996-04
3 Xuan Guowei, Fan Ruiqiang, Wu Yuansheng, Chen Hong, Zha Xushan. Department of Dermatology, The Second Affiliated Hospital of Guangzhou TCM University, Guangzhou 510120, China.;Study of HLA-DQ、DR and DP's Gene Polymorphism of SLE Patient of the Han Nationality in Guangdong[J];Southern China Journal of Dermato-Venereology;2003-04
4 Zhang Xiuwu, Zhang Zhijiong, Guo Xun, Guo Zhaogui (Department of Molecular Pharmacology, Hunan Medical University, Changsha, 410078);The Study on the Association Between the Hypertrophic Cardiomyopathy and HLA-DQ[J];Shanghai J.of Immunology;1997-01
5 Huang Xiao-Yu;Wang Ya-Xin;Wang Fu-Qing;Chen Shi-Shu(Department of Biochemistry and Laboratory of Molecular Biology, Deportment of Immunology, Shanghai Second Medical University, Shanghai 200025);Analysis of the Polymorphism at HLA-DRB1 Gene Locus by PCR-RFLP[J];;1996-06
6 CAO Xiu-jing,YE Dong-qing,LI Xiang-pei,et al (Department of Epidemiology Anhui Medical University,Hefei 230032,China);Study on the Association of HLA-DQA1 Alleles and Systemic Lupus Erythematosus in Anhui Hans Chinese[J];The Chinese Journal of Dermatovenereology;2004-02
7 WANG Hongluan,KUANG Jiulong,ZHOU Yeqing,et al.The Second Affiliated Hospital of Jiangxi Medical College.Nangchang,Jianxi 330006,China;Comparative study of HLA-DQA1 allele polymorphism in patients with asthma and chronic bronchitis[J];Chinese Journal of Respiratory and Critical Care Medicine;2004-02
8 GUO Xuejun, NI Peihua, LI Li, et al Department of Respiratory Medicine, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China;Association between asthma and the polymorphism of HLA-DQ genes[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2001-03
9 Zhang Wei, Chen Nan, Dong Dechang, et al. (Department of Nephrology Ruijin Hospital Shanghai Second Medical University, Shanghai 200025);Study on HLA-DQA1 , DQB1 genes associated with idiopathic membranous nephropathy[J];Chinese Journal of Microbiology and Immunology;1996-06
10 Lu Jianrong;Pan Xinghua;Zhu Renyuan et al.(Beijing Institute of Genetic Biology, Academi Sinica,Beijing 100080);STUDIES ON THE POLYMORPHISM OF HLA-DQA1 ALLELES IN JIANGSU,ZHEJIANG AND SHANGHAI HANS WITH PCR-RFLPMETHOD[J];CHINESE JOURNAL OF IMMUNOLOGY;1994-06
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Cheng Yuehua, Chen Ming Fan ChangbinLujiang Hospital of Traditional Chinese Medicine , Lujiang 231500;A meta-analysis on the association of HLA-DQ polymorphism and systemic lupus erythematosus in Chinese population[J];;2006-03
2 CHENG Yue-hua,CHENG Ming,FAN Chang-bin(Lujiang Hospital of Traditional Chinese Medicine,Lujiang 231500);A meta-analysis of the association of HLA-DQ polymorphism and systemic lupus erythematosus in Chinese population[J];Anhui Medical and Pharmaceutical Journal;2006-06
3 PAN Zheng-lun, ZHANG Yuan-chao, SUN Hong-sheng. Department of Rheumatology, Shandong Provincial Hospital, Shangdong University, Jinan 250021, China;Meta-analysis of the association between systemic lupus erythematosus with HLA-DQA1 in the Han nationality of Chinese in the mailand of China[J];Chinese Journal of Rheumatology;2006-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved