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《Shanghai J.of Immunology》 2001-01
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Effects of PPD on the Adhesion of Peripheral Blood Mononuclear Cells to Cultured Human Endothelial Cells of Umbilical Vein

YE Jun jie, ZENG Xiang yuan,CHEN Tao,LI Xiao jun(Clinical Experimental Laboratory,Chengdu Military General Hospital,Chengdu 610083)  
To investigate the effect of heat shock protein HSP60 on the development of initial stage in atherosclerosis,PPD(30 μg/ml) was used to observe its effect on the adhesion of peripheral blood mononuclear cells (PBMC) to human endothlial cells of umbilical vein The adhesion rates of PBMC to the cultured endothelial cells were determined,and the McAb CD54 or McAb IL 1β were to be used in the inhibition assays It was found that the adhesion rates of PBMC to the endothelial cells were increased in a time dependent manner when the latters were exposed with PPD,and were inhibited by McAb CD54,but not by McAb IL 1β It concludes that PPD could directly increase the expression of adhesion molecule CD54,which may be involved in the adhesion of PBMC to human endothelial cells of unbilical vein
【CateGory Index】: R392.12
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