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《Shanghai J.of Immunology》 2001-01
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Study of Association between Seronegative Spondyloarthropathy and HLA-DRB1 Genes

YANG Jue qin,YAO Fang juan,GE Yu,FAN Li an(Shanghai Institute of Immunology,Shanghai Second Medical University,Shanghai 200025)  
To investigate the association between seronegative spondyloarthropathies(SpA) and HLA DRB1 gene 214 B27 positive patients with SpA in Shanghai area and 13 cases of B27 positive controls and 150 normal individuals were genotyped for HLA DRB1 by PCR/SSO method The results showed that frequency of HLA DR12 gene was significantly increased in patients in comparison with normal controls and B27 positive control groups, Pc=0 0019, RR =1 988 The frequency of DR6 gene was significantly decreased in patients It suggests that HLA DR12 may be a susceptibility gene to SpA in Shanghai area and DR6 may play a protective effect to SpA.
【Fund】: 上海市教委和上海市联合利华发展基金
【CateGory Index】: R593.23
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