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《Shanghai J.of Immunology》 2001-03
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Changes of Insulin-like Growth Factors and Their Binding Proteins in Autoimmune Thyroid Disease

LIN Ling,WANG Jian,WANG Zhu lan,FENG Gen bao(Department of Endocrinology,Nanjing Military General Hospital,Nanjing 210002)  
To study the roles of alterations of the insulin like growth factor 1 (IGF 1),and insulin like growth factor binding proteins (IGFBP) in autoimmune thyroid disease (AITD),the levels of serum IGF 1,IGFBP 1~3 and thyroid hormones were measured by IRMA or RIA in fifty six AITD patients and twenty four normal controls The level of serum IGF 1 was significantly lower in AITD patients than those in the controls ( P 0 01);and the levels of IGFBP 1 and IGFBP 2 in GD group significantly higher than those of the controls ( P 0 01,0 05);however,the IGFBP 3 level in HT group was lower than that in normal controls ( P 0 05). No relationships between IGF 1 and thyroid hormones were found,although a positive correlation existed between IGFBP 1~3 and TT4( r =0 34,0 38,0 31; P 0 05). It seemed that the levels of serum IGF and IGFBP might be significantly affected by the thyroid function and the immunopathological status and might be involved in the pathogenesis of the AITD
【CateGory Index】: R581.03
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