Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Shanghai J.of Immunology》 2001-03
Add to Favorite Get Latest Update

Restricted Usage of Human TCR V_β Gene to Superantigen SEA and SEB

WANG Ying, LI Xue yi, SUN Wei, ZHANG Hui zhen, GE Hai liang, CHOU Kuang yan(Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025)  
As a kind of superantigen, staphylococcal enterotoxins(SE) can activate T cells via non MHC restricted and Vβ specific ways In this study, we analyzed the TCR Vβ usage pattern of normal periphery blood lymphocytes stimulated by three superantigens by quantitative PCR technique As a result, under different HLA genetic background they showed very similar usage patterns But with different sources of same superantigen, the TCR Vβ patterns were quite different Vβ3 and Vβ6 gene fragments were dominantly used by SEA stimulated T cells while oligoclonal proliferation of T cells with Vβ2、Vβ8 and Vβ9 and those with Vβ3, Vβ4, Vβ16, Vβ20 fragments owe to the stimulation of domestic(from Military Science Institute)and foreign SEB(from Sigma), respectively
【CateGory Index】: R392.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved