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《Shanghai J.of Immunology》 2001-03
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Studies on the Relationship Between CR1 Genomic Density Polymorphism of Erythrocytes and the NK Cell Activities in Patients with Ovarian Tumors

GUO Feng 1,ZHANG Jun jie 2,CUI Ying 2,XU Yu lian 3,SHEN Qian 3,XU Yu 3,QIAN Bao hua 1(1 Department of Transfusion;2 Department of Gyneco obstetris;3 Department of Laboratory Diagnosis,Changhai Hospital,The Second Military Medical Universi  
To investigate the relationship between CR1 genomic density polymorphism of erythrocytes and the NK cell activities in patients with ovarian tumors,the ECR1 genomic density polymorphism were detected by using PCR PFLP method,and the NK cell activities determined by cytotoxicity testing of the 3 H TdR labeled K562 cells in 51 patients with ovarian tumors and 40 normal individuals It was found that the NK cell activities of patients with ovarian tumors were remarkably decreased than those of normal individuals Nevertheless,the NK cell activities of those with highly expressed ECR1 genomic density polymorphism (HH type) were significantly higher than those with middle degree of expression group (HL type),but those of the latter were significantly higher than those of the lower expression group (LL type) These results indicate that the enhancement of NK cell activity by erythrocytes might be related to the ECR1 genomic density polymorphism
【Fund】: 国家自然科学基金资助项目 (批准号 :3 9670 75 4)
【CateGory Index】: R737.31
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