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《Shanghai J.of Immunology》 2003-01
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Purification and Identification of Pancreatic Cancer Associated Autoantigen 47

XIA Qing,ZHONG Ren qian,HOU Xiao jin,XUE Chao,CHEN Jun,KONG Xian tao(Department of Laboratory Diagnosis,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China)  
Previous works had detected a new autoantigen in patients with pancreatic cancers,called pancreatic cancer associated autoantigen 47 (PAA47) which was found in 63 64% of patients with pancreatic cancers and 1 9% of healthy controls The aim of the present study was to purify and identify the target antigen of this autoantigen by using the antigens extracted from human epithelial cells (Hep 2) and sera of 8 cases of precreatic cancers as confirmed by the positive reaction with anti 47 kD sera by SDS PAGE that was separated with two dimensional electrophoresis and then followed by mass electrophoresis identification To get some informations on the conformation and biological function of the antigen protein,software MASCOT and BLAST were used These results indicate that the gene product of KIAA0111 is a novel pancreatic cancer associated autoantigen and might be a potential serological marker for the pancreatic cancers
【Fund】: 卫生系统百名跨世纪优秀学科带头人培养计划资助项目[沪卫科 (1999) 2 1号 ]
【CateGory Index】: R735.9
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Chinese Journal Full-text Database 3 Hits
1 XIA Qing*, ZHONG Ren-qian, DENG An-mei, FAN Lie-ying, HAN Huan-xin, ZHOU Ye, CHEN Jun, HOU Xiao-jing, CHEN Yan, KONG Xian-tao. *Department of Laboratory Diagnosis, Changzheng Hospital, Shanghai 200003, China;cDNA cloning, expression of PAA47 and its significance in pancreatic cancer[J];Chinese Journal of Laboratory Medicine;2003-04
2 YU Gao-sheng,ZHENG Rui-ping.Department of General Surery,Heze Municipal Hospital,Heze 274031,China;Detection of interleukin-6 and autoantibody levels in colorectal cancer patients and its clinical significance[J];Chinese Archives of General Surgery(Electronic Version);2008-04
3 ZHANG Ying1,TANG Hua-ping1,LIU Shuang-mei1,WU Zeng-chun2,FENG Zhou2, GONG Qiao-li1,ZHANG Ming-yong1,HAO Wan-ming1,LI Meng1(1.Department of Respiratory Medicine,Qingdao Municipal Hospital,Qingdao,Shandong 266071,P.R.China;2.Yishui People's Hospital,Yishui,Shandong 276428,P.R.China);Relationship of auto-antibody in old people between lung cancer and COPD[J];China Journal of Modern Medicine;2011-02
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