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《Shanghai J.of Immunology》 2003-01
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Study on the Effect of Hemodialysis to the Peripheral Blood Level IL-18 in Patients with Chronic Renal Failure

XU Yong zhi,TANG De shen,LIAN Dong,JIANG Li ming,LIU Hua feng,LIU Hai yan,CHEN Xiao wen(Institute of Nephrology,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China)  
To investigate peripheral blood gene expression of interleukin 18 (IL 18) and the effect of hemodialysis (HD) to its expression in patients with chronic renal failure (CRF),the plasma level of IL 18 and expression of IL 18 mRNA in peripheral blood mononuclear cells (PBMC) were evaluated by enzyme linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT PCR) respectively in 10 healthy volunteers and 29 patients with chronic renal failure The results showed that the plasma level of IL 18 and expression of IL 18 mRNA in PBMC in patients with chronic renal failure were higher significantly than those of healthy controls They were not obviously changed after the first HD,but further increased significantly after two months of hemodialysis It suggested that high level of IL 18 expression in peripheral blood may play a significant role in pathogenesis of CRF and dialysis related morbidity
【CateGory Index】: R692.5
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