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《Current Immunology》 2007-01
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The biological activities of a novel immunosuppressive agent FK520

ZHENG Xiu-juan~(1),REN Xue-fang~(1),CHEN Gang~(1),TAO Li-min~(2),XIONG Si-dong~(1),WANG Ying~(1)(1.Institute for Immunobiology and Department of Immunology,Shanghai Medical College of Fudan University,Shanghai 200032,China;2.Shanghai Pesticide Research Institute,Shanghai 200032,China)  
To investigate the immunosuppressive effects of FK520,splenocytes from BALB/c mice were stimulated with(ConA),and T lymphocytes derived from DO(11.10) transgenic mice were enriched by nylon wool and then incubated with OVA_(323-329) peptide plus APC.Separately,5 weeks old nonobese diabetic(NOD) mice(n=20) were divided into two groups randomly and immunized by intramuscular injection with FK520(10 mg/kg) or with an equal volume of the dissolvent twice a week.The effects of FK520 on the body weight,blood sugar and insulitis of NOD mice were observed.The proliferations induced either by ConA or by specific antigen peptides could be inhibited by FK520 in a dose dependent manner.In addition,the IDDM incidence of NOD mice was reduced significantly by FK520(P0.05),which delayed the onset of the disease.From the observations in the present study,it is evident that FK520 shows a potent immunosuppressive effect and can be used as a potential therapeutic agent for autoimmune diseases.
【CateGory Index】: R979.5
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