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《Current Immunology》 2007-01
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Correlation between the level of IFN-γ in peripheral blood of patients with SLE and the activity of disease

ZENG Hui-qiong~(1),YE Zhi-zhong~(1),YIN Zhi-hua~(1),HE Ying~(2),GAO Jian-hua~(1),LUO Xiu-xia~(1)(1.Department of Rheumatology,Xiangmihu Branch of Shenzhen Fourth People's Hospital,Shenzhen 518040,China;2.Clinical Laboratory of Shenzhen Fourth People's Hospital,Shenzhen 518033,China)  
By using IFN-γ as the target of study,its relationship to the disease activity and renal damages of SLE was investigated in order to clarify the pathogenesis of this illness according to the evaluation with activity index,32 SLE patients were divided into active and stable groups,and based on the quantitative determination of urine albumin at 24 hours,they were divided into lupus nephritis(LN) and non-LN groups.In addition,20 healthy volunteers were closed as the control group.Three colored flow cytometry was used to detect the level of IFN-γ in the peripheral blood.As demonstrated by flow cytometry analysis,the percentages of CD45~(+)IFN-γ~(+)cells in the cell cultures and the expression of IFN-γ in patients with active SLE were higher than those in patients with stable SLE and healthy controls.In patients complicated with renal damages,the positive percentages of the IFN-γ level in the LN-groups were higher than those in the non-LN group of patients.A significant positive correlation between the SLEDAI scores and the percentage of IFN-γ expression could be demonstrated.These results indicate that positive correlation exists between the higher level of IFN-γ expression and the activity of disease and this may be used as a reference index for the acitivities of SLE.
【Fund】: 深圳市医学重点学科建设经费资助项目(深卫科发[2005]25号)
【CateGory Index】: R593.241
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