Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Current Immunology》 2009-01
Add to Favorite Get Latest Update

The relationship between the protein tyrosine phosphatase 22 gene 1123G>C single nucleotide polymorphism and systemic lupus erythematosus

FENG Xue1,LI Yong-zhe1,ZHANG Ji-lin2,QIN Xu-zhen1,ZHANG Yang1,BAO Shu-meng1,TONG Da-wei1,ZHANG Shu-lan1,HU Chao-jun1(1.Department of Medicine Rheumatology & Clinical Immunology Division,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,China;2.Department of Molecular Biology,Beihua University,Jilin 132013,China)  
To investigate the relationship between the protein tyrosine phosphatase 22(PTPN22) gene 1123GC single nucleotide polymorphism(SNP) and systemic lupus erythematosus(SLE),the real time fluorescent quantitation polymerase chain reaction was used to detect the 1123GC polymorphism of the PTPN22 gene from SLE patients,others rheumatic diseases and the normal controls.Antinuclear antibody(ANA) and anti-dsDNA were also detected.The result showed that there was a significant difference among SLE patients,others rheumatic diseases and the normal controls(P0.05).The CC genotype frequencies of SLE patients and the normal controls were 0.221 and 0.030 respectively;however there was no significant difference between others rheumatic diseases and the normal controls(P0.05).The results were consistent with law of Hardy-Weinberg equilibrium.There was no significant correlation between the positive ratio of ANA,anti-dsDNA,and the genotypes of PTPN22 gene(P0.05).It is evident that the polymorphism of PTPN22 gene is associated with SLE patients,and the genotypes of PTPN22 gene have no effect on the expression of ANA and anti-dsDNA.
【Fund】: 国家自然科学基金资助项目(30471617、30640084);; 国家高技术研究发展计划(863计划)基金资助项目(2006AA02Z436)
【CateGory Index】: R593.241
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 YANG Xiao-lei,DENG Dan-qi.(Dermatology,Second Affiliated Hospital of Kunming Medical College,65101);Research progress of systemic lupus erythematosus′ predisposing gene SNPs[J];Chinese Journal of Birth Health & Heredity;2011-02
Chinese Journal Full-text Database 1 Hits
1 SU li1,2,YU Xin-pei1,ZHANG Li-yun1,KUREXIJIANG Tuofuti3,CHEN Zheng-liang1(1.Department of Immunology,Southern Medical University,Guangzhou 510515,China;2.Department of Microbiology,Guiyang Medical College,Guiyang 550004,China;Moyu Hospital of Hetian Distric,Xinjiang Uigiur Autonomous Region,Moyu 848100,China);Single nucleotide polymorphisms,haplotypes and genotypes of mannan-binding lectin gene in the Uigur population[J];Current Immunology;2007-02
Chinese Journal Full-text Database 10 Hits
1 LIU Lin, XU Ling-hua (Dept of Rheumatism, Xuzhou City Center Hospital, Xuzhou 221009,China);Pulmonary manifestation in mixed connective tissue disease[J];Anhui Medical and Pharmaceutical Journal;2004-06
2 GUO Zhao-jun1,LI Xiang-pei2,SONG Wei-ya2(1.The First People's Hospital,Huainan,Anhui 232000,China;2.Provincial Hospital,Anhui Medical University,Hefei,Anhui 230001,China);Clinical analysis of 50 cases of systemic sclerosis[J];Anhui Medical and Pharmaceutical Journal;2010-07
3 CHEN Ji fan ,HUANG Qing chun ,CHEN Guang xing,YE Liu zhong,LIU Qing ping,LI Xiao juan (Guangzhou University of Traditional Chinese Medicine, Guangdong Guangzhou 510010,China);Effect of Tongbiling on Pathology of Synovial Membrane in CIA Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-02
4 WU Xiao li,LI Yu yun,MEN Yin,XU Hui yun,ZHANG Qiang,HAO Yan mei (Department of Clinical Laboratories and Diagnostics,Bengbu Medical College,Anhui 233003,China);The anticardiolipin antibodies test in patients with lupus nephritis and its clinical significance[J];Journal of Bengbu Medical College;2004-01
5 Song Zezhou*,Ma Jing,Zeng Huiru,et al *Department of Ultrasound,the First Affiliated Hospital, College of Medicine,Zhejiang University,Hangzhou 310003 China;Speciality of Parotid Gland Ultrasonography in Primary Sjgren's Syndrome[J];Chinese Journal of Ultrasound Diagnosis;2005-09
6 ;类风湿关节炎患者IL-17、IL-18、IL-6和TNF-α检测的意义[J];Contemporary Medicine;2010-07
7 HUANG Li-qun,HUNAG Shao-bi.First Affiliated Hospital, Shantou University Medical College, Shantou 515041,China;Clinical Significance of Troponin Testing in Rheumatic Diseases with Myocardial Injury[J];Journal of Chinese Physician;2003-10
8 HOU Wei,HUI Yan (Department of Dermatology of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China);Clinical Study of Antineutrophil Cytoplasmic Antibodies in 65 Patients with Systemic Lupus Erythematosus[J];Endemic Disease Bulletin;2005-02
9 HE Hong, WU Li-hua, LI Shang-zhu, CHU Yu-lin (Department of Internal Medicine,DaLi Medical College,DaLi 671000,China);The Hematology Abnormal in Systemic Lupus Erythematosus[J];Journal of Dali Medical College;2000-04
10 REN ChongLei1, LIU WeiYong, ZHANG JinBao1, YAN PeiSong2 1Center of Cardiovascular Surgery, 2Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Expression of transforming growth factor-β1 and activator protein-1 in papillary muscles of patients with rheumatic heart disease[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-05
Chinese Journal Full-text Database 3 Hits
1 GAO Shu-na1, JIANG Zong-min1,4, MENG Wei1,5△, JIANG Feng1, GU Wei-min2, HU Wei-zhong2, FU Chao-wei1, XU Ai-er3, LAI Sheng-han5△(1Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China; 2Department of Clinical Lab,Shanghai Skin Disease & Sexually Transmited Disease Hospital 200050, China; 3Department of Dermatology, Third People′s Hospital of Hangzhou 310009, China; 4The Research Institute of Family Planning in Shanghai 200032, China; 5Department of Pathology, School of Medicine, Johns Hopkins University,Baltimore, MD 21287, USA);Cytotoxic T lymphocyte-associated antigen-4 gene promoter polymorphisms in patients with systemic lupus erythematosus in southern Chinese population[J];Fudan University Journal of Medical Sciences;2007-02
2 Pan Faming,Zhang Kechun,Li Xiangpei,et al(Dept of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032);Genetic susceptibility and haplotype analysis between Fcγ receptorⅡB and ⅢA gene with systemic lupus erythematosus in Chinese population[J];Acta Universitatis Medicinalis Anhui;2008-02
3 SONG Wei-qing,LI Hua-hui,CHEN Hua-bo,et al.(Department of Laboratory Medicine,Qingdao Municipal Hospital,Qingdao 266011,China);Study on Relationship Between Polymorphism Site rs10954213 of IRF5 and SLE Patients[J];Chinese Journal of Laboratory Diagnosis;2009-08
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 HE Zhi, CHEN Zheng-liang (Department of Immunology, Southern Medical University, Guangzhou 510515,China);Cloning and prokaryotic expression of the N-terminal fragment of mouse long type peptidoglycan recognition protein (mPGRP-L)[J];;2005-05
2 CHEN Zhengliang (Department of Immunology, The First Military Medical University, Guangzhou 510515, China).;Mammalian C-Type Lectin Superfamily.[J];Progress In Biochemistry and Biophysics;1997-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved