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《Current Immunology》 2009-01
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The changes of IL-10,TGF-β1 and CD4~+CD25~+T cells during specific immunotherapy for children with allergic asthma

LI Fu-guang1,WANG Fang1,YANG Gui-zhi1,ZHU Sha1,LI Yu-qin2(1.Department of Microbiology and Immunology;2.Department of Pediatics of the First Affiliated Hospital,Zhengzhou Univercity,Zhengzhou 450001,China)  
The current study was designed to investigate the machanisms of allergen specific immunotherapy(SIT) by detecting the changes of IL-10,TGF-β1 and CD4+CD25+ T cells and the efficiency during specific immunotherapy for children with allergic asthma.In this study,the patients with allergic asthma were divided into three groups: i.e.pre-SIT,post-SIT for 1 year and post-SIT for 2 years.The IL-10 and TGF-β1 mRNA in PBMCs were detected by SYBR Green I real-time RT-PCR and the percentage of CD4+CD25+ T cells and CD4+CD25high T cells in peripheral blood CD4+ T cells was evaluated with flow cytometry.At the same time,the changes of PEF and areas of welt in skin test were recorded,and the clinical effects were detected.It was found that the expression of IL-10 mRNA in post-SIT for 1 year group was much higher than that of pre-SIT group,but it reduced in post-SIT for 2 years group;While the expression of TGF-β1 mRNA had no significant changes during the SIT.The percentage of CD4+CD25+ T cells in peripherral blood CD4+ T cells showed no significant change during the SIT(P0.05);The percentage of CD4+CD25highT cells in peripheral blood CD4+ T cells in post-SIT for 1 year group was much higher than that of pre-SIT group(P0.05),and it retained in high level in post-SIT for 2 years group with alleviation of clinical symptoms.It is concluded that allergen specific immunotherapy is efficient for the patients with allergic asthma,in which IL-10 and CD4+CD25high T cells could play an important role in this process.
【Fund】: 河南省卫生厅科技攻关研究资助项目(200703003)
【CateGory Index】: R725.6
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