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《Current Immunology》 2009-01
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The changes of IL-10,TGF-β1 and CD4~+CD25~+T cells during specific immunotherapy for children with allergic asthma

LI Fu-guang1,WANG Fang1,YANG Gui-zhi1,ZHU Sha1,LI Yu-qin2(1.Department of Microbiology and Immunology;2.Department of Pediatics of the First Affiliated Hospital,Zhengzhou Univercity,Zhengzhou 450001,China)  
The current study was designed to investigate the machanisms of allergen specific immunotherapy(SIT) by detecting the changes of IL-10,TGF-β1 and CD4+CD25+ T cells and the efficiency during specific immunotherapy for children with allergic asthma.In this study,the patients with allergic asthma were divided into three groups: i.e.pre-SIT,post-SIT for 1 year and post-SIT for 2 years.The IL-10 and TGF-β1 mRNA in PBMCs were detected by SYBR Green I real-time RT-PCR and the percentage of CD4+CD25+ T cells and CD4+CD25high T cells in peripheral blood CD4+ T cells was evaluated with flow cytometry.At the same time,the changes of PEF and areas of welt in skin test were recorded,and the clinical effects were detected.It was found that the expression of IL-10 mRNA in post-SIT for 1 year group was much higher than that of pre-SIT group,but it reduced in post-SIT for 2 years group;While the expression of TGF-β1 mRNA had no significant changes during the SIT.The percentage of CD4+CD25+ T cells in peripherral blood CD4+ T cells showed no significant change during the SIT(P0.05);The percentage of CD4+CD25highT cells in peripheral blood CD4+ T cells in post-SIT for 1 year group was much higher than that of pre-SIT group(P0.05),and it retained in high level in post-SIT for 2 years group with alleviation of clinical symptoms.It is concluded that allergen specific immunotherapy is efficient for the patients with allergic asthma,in which IL-10 and CD4+CD25high T cells could play an important role in this process.
【Fund】: 河南省卫生厅科技攻关研究资助项目(200703003)
【CateGory Index】: R725.6
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Chinese Journal Full-text Database 1 Hits
1 HE Jun,ZUO li(Department of Immunology,Guiyang Medical College,Guiyang 550004,China);Study on the level of TGF-β1 in sera from heroin addicts[J];Current Immunology;2011-01
Chinese Journal Full-text Database 1 Hits
1 YU Bo, HE Wei, ZHANG Bin, YANG Ling, WU Jun (Department of Dermatology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China);Effects of dexamethasone on the expression of glucocorticoid receptor α in human keratinocyte HaCaT cell line[J];Journal of Clinical Dermatology;2008-04
Chinese Journal Full-text Database 7 Hits
1 Xu Yiping; Zhu Lijun; Yao Suhang; Sun Liming(Research Laboratory of Chronic Obstructive Pulmonary Disease,Renji Hospital,Shanghai 2nd Medical University,Shanghai 200001);Relationships between Plasma SIL-2R and Eosinophil Count,Basophil Count,IgE in Allergic Asthma[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1996-04
2 YANG Ling,HE Wei,LI Ying,ZHANG Bin ( Department of Dermatology,Xinqiao Hospital,Third Military Medical University, Chongqing 400037,China);Expression of glucocorticoid receptor in HaCaT cells under dexamethasone treatment or after withdrawal[J];Acta Academiae Medicinae Militaris Tertiae;2009-21
3 Lai Xinsheng Situ Ling Jin Rui Zhang Jiawei Acupuncture Department, Guangzhou College of Traditional Chinese Medicine Lai Naikui He Zilan Xiong Weiyang Chen Xiaoyou The Second Affiliated Hospital of Guangzhou College of Medicine;Effect of Acupuncture on Basophilic Degranulation Test(BDT) of Patients with Type Ⅰ Hypersensitivity[J];;1991-04
4 Xu Yiping Hu Bingxiong Yu Yongjuan Dai Shunying Huang Dingjiu Research Laboratory for Chronic Obstructive Pulmonary Disease, Renji Hospital, SSMU, Shanghai;RELATIONSHIP BETWEEN IgD AND ASTHMA[J];上海第二医科大学学报(英文版);1987-01
5 Xu Yiping, Zhu Lijun, Yao Suhang, Shen Qiyun, Sun Limin (Research Laboratory of Chronic Obstructive Pulmonary Disease, Renji Hospital, Shanghai 2nd Medical University, Shanghai, 200001);Relationship Among Plasma IL-4 and IgE, Basophil in Allergic Asthma[J];Shanghai J.of Immunology;1997-02
6 Xu Yiping, Yao Suhang, Deng Yaodong , et al. (Research Laboratory of Chronic Obstructive Pulmonary Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai, 200001; Shanghai Medical University);Changes of the Blood IgE, Eosinophil and Basophil Levels in Asthmatics with Remission during Puberty[J];Shanghai J.of Immunology;1997-05
7 WU Jingliang,JI huaan,XIAO Yin,CHEN Donglai,LIU Gang,ZHANG Litao Tianjin Medical University,Tianjin 300070,China;Expressions of Glucocorticoid Receptor α and β in Lesions of Facial Steroid-dependent Dermatitis[J];Tianjin Medical Journal;2009-06
China Proceedings of conference Full-text Database 1 Hits
1 wu Jing-liang~1 ji hua-an~2 xiao yin~2 chen dong-lai~2 liu gang~2 zhang li-tao~2 (1.Tianjin medical university,tianjin 300070,China;2.Tianjin Chang-Zheng Hospital,tianjin 300120,China);Expression of glucocorticoid receptorαandβin lesion of facial steroid dependence dermatitis[A];[C];2008
Chinese Journal Full-text Database 10 Hits
1 MA Xiang-Ping,Duolikun.Department of Pediatrics,First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China;Efficacy of sublingual immunotherapy in children with dust mite allergic asthma[J];Chinese Journal of Contemporary Pediatrics;2010-05
2 JIN Ting-ting,ZHANG Xiao-bo,ZHANG Ming-zhi,ZHANG Hao,REN Ci-fang,FENG Hai-yan,WANG Li-bo(Department of Respiratory,The Children's Hospital of Fudan University,Shanghai 201102,China);The systemic adverse effects of specific immunotherapy in children of asthma[J];Journal of Clinical Pediatrics;2010-05
3 JI Ning-fei,BIAN Tao,YIN Kai-sheng*(Department of Respiratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China);Effects of dexamethasone on expression of the transcription factor GATA-3 in asthmatic rats[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2006-09
4 CHEN Cun-guo1,LI Shao-bo1,WANG Xin-xin1,JIN Xiao-hong1,TONG Xia-sheng2,LAI Xiao-ying11Department of Internal Medicine,Taizhou Hospital,Linhai 317000,Zhejiang,China;2Department of Internal Medicine,Combination of TCM with Western Medicine of Taizhou,Wenling 317523,Zhejiang,China;Effects of specific immunotherapy on IL-10 and CD_4~+CD_(25)~+ regulatory T cells in asthmatic rats[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2010-08
5 YANGAixia1,WANGJiajun2,LIUDongliang1,WEIJingjun2 1(DrugDetoxificationCenterofNo.473AirForceHospital,Lanzhou,730070) 2(DepartmentofNuclearMedicineofNo.473AirForceHospital,Lanzhou,730070);STUDY ON THECHANGES OF IL -1,IL -2ANDTNF LEVEL IN SERUM OF HEROIN ADDICTS[J];CHINESE JOURNAL OF DRUG DEPENDENCE;2000-03
6 LU Hai,BAI Bo,SONG Wen-gang.(Department of Neurobiology,Taishan Medical College,Taian 271000,China);Advances in Effects of Opioids and Opioid Receptors on Immune System[J];Medical Recapitulate;2009-18
7 XU Lei,ZHAO Chao,XIAO Wen,et al.(Department of Respiration,Zhongshan Municipal Boai Hospital,Zhongshan Guangdong 528403,China);Effects of specific immunotherapy on pulmonary function of patients with asthma[J];Practical Journal of Clinical Medicine;2007-05
8 BAI Jian-wen, DENG Wei-wu, WU Hua-cheng. Department of Respiratory Medicine,Ruijin Hospital,Shanghai Second Medical University, Shanghai 200025, China;The effect of montelukast on airway remodeling and the expression of interleukins and transforming growth factor-β2 mRNA[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2004-08
9 FAN Da-ping,ZHANG Yi-mei HUO Jian min Department of Respiratory Disease,the First Clinical College of Harbin Medical University,Harbin 150001,China;Expression of TGF-β1 in the serum and induced sputum in asthmatic patients[J];Chinese Journal of Critical Care Medicine;2006-10
10 LIU Ping-li, LV Li-li, XIA Chun-wei, LI Ruo-ran, YAO Hong-wei ZHU Shu-yang (Department of Respiratory, the Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221008, P.R.China);Effects of Dexamethsone on proliferation of airway smooth muscle cells and transforming growth factor-β1 in chronic asthma mice[J];China Journal of Modern Medicine;2008-10
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 LI Bo, BAI Xiangjun, WANG Haiping .Department of Trauma Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030,China;Effects of dexamethasone on expression of glucocorticoid receptor in human monocyte cell line THP-1[J];Chinese Journal of Emergency Medicine;2006-06
2 YANG Ling, HE Wei, LI Zhi, WU Jun, LIN Zi-hua, HE Yun-zhi, HUANG Hai (Department of Dermatology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China);Expression of GR-α, NF-κB, TNF-α and IL-1β in chronic dermatitis[J];Journal of Clinical Dermatology;2006-05
3 XU Mingjuan , SONG Liangnian WANG Zhaomei Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Effects of Dexamethasone on glucocorticoid receptor expression in a human ovarian carcinoma cell line 3AO[J];中华医学杂志(英文版);2003-03
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