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《Current Immunology》 2009-01
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Investigation and sequencing analysis on the HLA-A and B-relevant genes in Henoch-purpura of children of Mongolian and Han populations in internal Mongolia region

REN Shao-min,YANG Guang-lu,LIU Chun-zhi,ZHANG Chun-xia,YU Shao-fei,LI Wei-cai(Department of Pediatrics,the First Affiliated Hospital of Inner Mongolia Medical College,Huhehot 010050,China)  
The relationship of the HLA-A and B-relevant genes and the Henoch-purpura in children of Mongolian and Han population in internal Mongolian region as well as the sequencing analysis were investigated.In the present study,56 Mongolian children and 50 Han population children with anaphylactoid purpura(AP) were selected for study,whose ancestral homes in three generations were all situated at internal Mongolian region,having no any blood-relationship and without history of mixed marriages or family history of presence of autoimmune diseases.Meanwhile,66 healthy Mongolian children and 96 healthy Han population children were taken as the normal controls.The polymorphism of the HLA-A and B alleles was analyzed by PCR-SSO technology,and the sequencing analysis for the susceptibility genes was undertaken by PCR-sequence based typing(PCR-SBT) with high discrimination.It was found that the gene frequencies of HLA-A*11 and HLA-B*15 of Mongolian children with AP were significantly higher than those of the normal controls(P0.05),while those of HLA-B*07 and HLA-B*40 were much lower than those of the normal controls(P0.05).Nevertheless,the gene frequencies of HLA-A*26 and HLA-B*35 in Han population children with AP were much higher than those of control groups(P0.05).Both in Mongolian and Han population children with AP,no gene mutation site could be found.From these observations,it is evident that HLA-A*11 and HLA-B*15 may be the susceptibility genes for Mongolian children with AP and HLA-B*07 and HLA-B*40 seem their protection genes;however,the susceptibility genes in Ham population children with AP are HLA-A*26 and HLA-B*35.
【CateGory Index】: R725.54
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