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《Current Immunology》 2011-01
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The expression of IFN-inducible T cell alpha chemoattractant on microglia was induced by Beta-Amyloid

HU Hai-xia1,2,ZHANG Qiu-yu3,WU Lin-qing3,SU Dong-hui3(1.Academy of Intergrative Medicine;2.Fujian University of Traditional Chinese Medicine;3.Department of Immuology,Fujian Medical University,Fuzhou 350108,China)  
It is well known that microglia play an important role in the pathogenesis of chronic inflammation of central nervous system.The aim of the present study was to detect the expression of chemokine IFN-inducible T cell alpha chemoattractant(I-TAC) on microglia and the potential role of I-TAC on T cell proliferation and differentiation.The expression of I-TAC mRNA was analyzed by RT-PCR,and the primary mouse T cells were isolated and purified by nylon wool.Effect of I-TAC on the proliferation of T cells was investigated by MTT assay,and the expression of CD11a on T cells was measured by FACS.It was found that the expression of I-TAC in microglia was induced by Beta-Amyloid,LPS and IFN-γ,and the recombinant murine I-TAC could promote the proliferation of T cells as well as induced T cell to produce IFN-γ.Furthermore,I-TAC significantly promoted the expression of CD11a(LAF-1) on T cells.The results of present study suggest that I-TAC play an important role in the development of chronic inflammation of neurological system.
【Fund】: 福建省教育厅重点项目(JA02217);; 福建医大博士启动基金(2009BS003)
【CateGory Index】: R392
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHU Xian-jin,ZHANG Qiu-yu,XU Wei-qun,WU Lin-qing,SU Dong-hui(Department of Immuology,Fujian Medical University,Fuzhou 350001,China);Effect of mycophenolate acid on the expression and functions of IFNinducible T cell α-chemoattractant[J];Current Immunology;2006-02
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 ZHU Xianjin1,SONG Yanfang2,XU Weiqun3,ZHANG Qiuyu3,SU Donghui3 1.Department of Laboratory,The Affiliated Union Hospital,Fujian Medical University,Fuzhou 350001,China2.Department of Laboratory,Fujian Province People's Hospital,Fuzhou 350004,China3.Department of Immuology,Fujian Medical University,Fuzhou 350004,China;An in vitro Study on the Expression of IFN-inducible T Cell Alpha Chemoattractant and its Receptor Induced by Alloimmune Reaction[J];Journal of Fujian Medical University;2008-06
2 XU Jun,LONG Li. ( Department of Cell Biology and Genetics,Kunming Medical College,Kunming 650031,China);Effects of Chemokines and Their Receptors in the Nervous System Diseases[J];Medical Recapitulate;2010-21
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