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《Current Immunology》 2011-01
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The single nucleotide polymorphism and haplotype of FCAMR gene in the northwestern Han populations of China

NIU Dan1,LI Yun-xia1,GENG Ying-zhou1,LU Wan-hong1,Lü Jing1,LIU Qing-bo2,HAO Ya-ning1,LI Sheng-bin2(1.Department of Nephrology,First Affiliated Hospital,College of Medicine,Xi'an Jiaotong University,Xi'an 710061,China;2.Forensic Medicine College,Xi'an Jiaotong University,Xi'an 710061,China)  
To investigate the single nucleotide polymorphism and haplotype structure of Fc receptor IgA,IgM high affinity(FCAMR) genes T549C(rs1856746),A457G(rs3813952),G421A(rs1340232) and A298G(rs3813950) in the northwestern populations of China,the genotypes of these FCAMR genes were determined in 79 un-related northwestern Han healthy populations(45males and 34females) by using polymerase chain reaction and followed by sequeencing,and the frequency of haplotypes and linkage disequilibrium of FCAMR genes were analyzed by SHEsis programs.For the T549C(rs1856746) polymorphism,the frequency of C allele was found to be 38.6%,and the T allele was 61.4%,for A457G(rs3813952) polymorphism the frequency of G allele was 5.7%,A allele was 94.3%,for G421A(rs1340232) polymorphism the frequency of A allele was 17.1%,G allele was 82.9%,and for A298G(rs3813950) polymorphism,the frequency of G allele was 4.4%,and A allele was 95.6%.Three major haplotypes(defined as more than 10% occurrence for each)of T/A/G/A,C/A/A/A and C/A/G/A were observed in the northwestern Han populations,and the frequency of T/A/G/A was 60.5%,C/A/A/A was 17.1% and C/A/G/A was 16.7%.This investigation appears to be the first study to demonstrate the polymorphism of the FCAMR genes T549C(rs1856746),A457G(rs3813952),G421A(rs1340232) and A298G(rs3813950) in northwestern Han populations.The genotype and haplotype analysis from these data may be used as a basis for the studies on the relationship between FCAMR genotypes and immune reactions or disease susceptibility,such as IgA nephropathy in northwestern Han populations of China.
【Fund】: 陕西省卫生厅科研项目(06D34)
【CateGory Index】: R392.4
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