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《Current Immunology》 2011-01
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The single nucleotide polymorphism and haplotype of FCAMR gene in the northwestern Han populations of China

NIU Dan1,LI Yun-xia1,GENG Ying-zhou1,LU Wan-hong1,Lü Jing1,LIU Qing-bo2,HAO Ya-ning1,LI Sheng-bin2(1.Department of Nephrology,First Affiliated Hospital,College of Medicine,Xi'an Jiaotong University,Xi'an 710061,China;2.Forensic Medicine College,Xi'an Jiaotong University,Xi'an 710061,China)  
To investigate the single nucleotide polymorphism and haplotype structure of Fc receptor IgA,IgM high affinity(FCAMR) genes T549C(rs1856746),A457G(rs3813952),G421A(rs1340232) and A298G(rs3813950) in the northwestern populations of China,the genotypes of these FCAMR genes were determined in 79 un-related northwestern Han healthy populations(45males and 34females) by using polymerase chain reaction and followed by sequeencing,and the frequency of haplotypes and linkage disequilibrium of FCAMR genes were analyzed by SHEsis programs.For the T549C(rs1856746) polymorphism,the frequency of C allele was found to be 38.6%,and the T allele was 61.4%,for A457G(rs3813952) polymorphism the frequency of G allele was 5.7%,A allele was 94.3%,for G421A(rs1340232) polymorphism the frequency of A allele was 17.1%,G allele was 82.9%,and for A298G(rs3813950) polymorphism,the frequency of G allele was 4.4%,and A allele was 95.6%.Three major haplotypes(defined as more than 10% occurrence for each)of T/A/G/A,C/A/A/A and C/A/G/A were observed in the northwestern Han populations,and the frequency of T/A/G/A was 60.5%,C/A/A/A was 17.1% and C/A/G/A was 16.7%.This investigation appears to be the first study to demonstrate the polymorphism of the FCAMR genes T549C(rs1856746),A457G(rs3813952),G421A(rs1340232) and A298G(rs3813950) in northwestern Han populations.The genotype and haplotype analysis from these data may be used as a basis for the studies on the relationship between FCAMR genotypes and immune reactions or disease susceptibility,such as IgA nephropathy in northwestern Han populations of China.
【Fund】: 陕西省卫生厅科研项目(06D34)
【CateGory Index】: R392.4
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiao-yan 1,3,CHEN Guang-jie 1,QIN Ying 1,2(1,Shanghai Jiaotong University Medical School,Shanghai Institute of Immunology,Shanghai 200025,China;2,Institute of Nutritional Sciences,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China;3.Affiliated Hospital of Nantong University,Nantong 226001,China);Construction of four different novel chimeric immune receptors[J];Current Immunology;2008-04
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【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 ZHENG Qi-Cheng,FENG Yi,XIAO Li,LIANG Xiao-Ling,YU Jie Department of Hemooncology,Children's Hospital,Chongqing Medical University,Chongqing 400014,China;MDR1 gene single nucleotide polymorphism and haplotype in Chongqing Han populations[J];Journal of the Fourth Military Medical University;2009-22
2 TANG Hui-lin, HU Yong-fang(Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China);Systematic review of influence of MDR1C1236T genetic polymorphism on cyclosporine pharmacokinetics[J];The Chinese Journal of Clinical Pharmacology;2010-04
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 JIAO Zheng,LIANG Hui-qi,DING Jun-jie,LI Zhong-dong,SHI Xiao-jin,ZHONG Ming-kang * (Clinical Pharmacy Laboratory,Huashan Hospital,Fudan University,Shanghai 200040,China);Effect of MDR1 polymorphic expression on oral disposition of cyclosporine A[J];Acta Pharmaceutica Sinica;2004-12
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