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《Current Immunology》 2011-01
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Study on the level of TGF-β1 in sera from heroin addicts

HE Jun,ZUO li(Department of Immunology,Guiyang Medical College,Guiyang 550004,China)  
By detecting the serum levels of TGF-β1 from heroin addicts for a further exploration on the effect of heroin in the immune function of the addicts,99 cases of heroin addicts were divided into 3 groups according to the duration of employing heroin,i.e.group within 2 years;group within 5~10 years and group over 10 years,and 33 cases of normal human sera were used as the control group.The levels of TGF-β1 in the sera of various groups were detected by double antibody sandwich ELISA assay.It was found that the serum TGF-β1 levels in various groups of heroin addicts were lower than that of the normal control group(P0.05).The levels of TGF-β1 was decreasing along with prolongation in the time of heroin addiction(99.92±38.35 pg/ml for groups within 2 years,91.72±67.78 pg/ml for groups within 5~10 years,and 53.51±27.32 pg/ml for groups over 10 years,respectively).It is evident that the level of TGF-β1 in sera from the heroin addicts changed significantly,indicating that heroin can inhibit the expression of TGF-β1 in the body.
【CateGory Index】: R749.64
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