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《Current Immunology》 2014-01
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HDAC1 regulates expression of Cyr61 in inflammatory synovial cells through NF-κB

LI Hui-dan;SUN Yue;HUO Rong-fen;SHEN Bai-hua;LI Ning-li;Shanghai Institute of Immunology,Shanghai Jiaotong University,Shanghai School of Medicine,Institutes of Medical Sciences;  
We investigated the role of histone deacetylase enzyme 1(HDACl) in IL-17-induced upregulation of Cyr61 in synovial cells of rheumatoid arthritis(RA).The pattern of expression of HDACl in synovial tissues and synoviocytes was examined by real-time PCR,and so do the expression pattern of Cyr61 induced by IL-17 after adding HDAC inhibitor trichostatin(TSA)/niacinamide(NAM) and/or specific inhibitor of NF-kB(PDTC) to RA synovial cells.The results showed that HDACl was overexpressed in RA synovial tissues as well as in IL-17- stimulated synoviocytes by.The inhibitor of HADC1.TSA,but not NAM,could enhanc the expression of IL-17- induced Cyr61 in synoviocytes.But this effect of enhancement was offset by PDTC.This study has illuminated that HDACl plays an important role in the expression of IL-17- induced Cry61 in synovial cells and the mechanism may be correlated with regulation of NF-kB activity.
【Fund】: 973项目(2010CB529103);; 上海市教委(J50207)
【CateGory Index】: R363
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