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《Current Immunology》 2014-03
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Associations of HLA-DP polymorphisms with chronic hepatitis B virus infection and hepatocellular carcinoma in Chinese population:a Meta-analysis

SU Ming-kuan;ZENG Yong-bin;CHEN Jing;LIU Can;CHEN Tian-bin;YANG Bin;OU Qi-shui;The First Clinical Medical College of Fujian Medical University;Department of Laboratory Medicine,The First Affiliated Hospital,Fujian Medical University;  
To assess the rigorous relationship between HLA-DP polymorphisms(rs3077,rs9277535)and outcomes of chronic hepatitis B virus(HBV)infection by mean of Meta-analysis,a Meta-analysis was conducted with the data from ten relevant papers and three of ten studies related to hepatocellular carcinoma(HCC),following strict selection.The pooled odds ratios(OR)with 95%confidence intervals(CI)were calculated using fixed-or random-effects model when appropriate.Funnel plot and Egger's test was used to measure publication bias.Our analysis suggested that these HLA-DP polymorphisms not only protect against chronic HBV infection(rs3077:OR=0.57,95%CI:0.53~0.63;rs9277535:OR=0.56,95%CI:0.51~0.61),but also served as protective factors in the spontaneous clearance of HBV(rs3077:OR=0.60,95%CI:0.52~0.68;rs9277535:OR=0.59,95%CI:0.54~0.64),and the presence of the A allele at rs3077 of the HLA-DP gene may decreased the risk for HCC(OR=0.83,95%CI:0.74~0.93)under the dominant model.
【Fund】: 国家自然科学基金(81371888);; 福建省高校产学合作科技重大项目(2013Y4002)
【CateGory Index】: R735.7
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