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《Current Immunology》 2015-01
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The relationship between the IL-17-induced expression of SENP6 and Cyr61 in FLS from human rheumatoid arthritis

ZHAI Tian-hang;SUN yue;HUO Rong-fen;SHEN Bai-hua;LI Ning-li;Shanghai Institute of Immunology,Shanghai Jiao Tong University,Shanghai School of Medicine,Institute of Medicine Science;  
This study aimed to investigate the role of SENP6 in IL-17 induced up regulation of Cyr61 in fibroblast like synoviocytes(FLS)of Rheumatoid arthritis(RA).The expression pattern of SENP family members and Cyr61 in FLS induced by IL-17 was examined by real-time PCR.The results showed that the SENP6 and the Cyr61 were overexpressed in IL-17-stimulated FLS from four of the eight RA patients.As for IL-17-stimulated FLS from the other four patients,both the SENP6 and the Cyr61 expression showed no difference compared to the control.Linear regression reveals positive correlation in the SENP6 expression with the Cyr61 expression in FLS induced by IL-17,which implies that SENP6 may play an important role in up regulation of Cyr 61 in IL-17-stimulated FLS.
【Fund】: 973项目(2010CB529103);; 上海市教委基金(J50207)
【CateGory Index】: R593.22
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