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《Current Immunology》 2015-01
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Serum expression and clinical significance of Nov/CCN3 in human hepatocellular carcinoma

WANG Meng-meng;JI Jun;CHENG Cheng;GAO Chun-fang;Department of Laboratory Medicine,Eastern Hepatobiliary Hospital,Second Military Medical University;  
To investigate the expression of nephroblastoma overexpressed(NOV/CCN3)gene in the serum of hepatocellular cancer(HCC)and liver cirrhosis(LC)and to evaluate the relationship between the level of NOV and the progression of hepatocellular carcinoma,a newly developed commercial assay for detection of NOV in the body fluids was adopted.We investigated levels of serum NOV in 380 samples of human HCC and,92 samples of LC as well as 102 samples of healthy controls.The relationship between NOV/CCN3 levels and the clinical pathological features were also evaluated.The concentrations of NOV in LC was significantly higher than those in HCC and healthy controls(P0.001).For distinguishing LC from healthy controls,NOV had a sensitivity of 67.4%and specificity of 73.5% [area under curve(AUC):0.741]at the cutoff level of 7.812ng/ml by applying receiver operating characteristic(ROC)curve analysis.In HCC group,the NOV concentration was negatively correlated with clinical-pathological features,including tumor size and TNM stage.The area under ROC curve(AUC)of NOV in AFP-negative population was 0.803.The optimal cutoff point of NOV was 7.68ng/ml,with the sensitivity being 83.8% and the specificity being 71.6%.In conclusion,NOV might be helpful in the differential diagnosis between liver cirrhosis and AFPnegative HCC,and may play a negative regulatory role in the evolution of HCC.
【Fund】: 国家自然科学基金资助项目(81301516)
【CateGory Index】: R735.7
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【Co-citations】
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1 Tsu-Yao Cheng;Ming-Shiang Wu;Kuo-Tai Hua;Min-Liang Kuo;Ming-Tsan Lin;Department of Laboratory Medicine,National Taiwan University Hospital;Department of Internal Medicine,National Taiwan University Hospital;Graduate Institute of Toxicology,National Taiwan University College of Medicine;Department of Surgery,National Taiwan University Hospital;;Cyr61/CTGF/Nov family proteins in gastric carcinogenesis[J];世界胃肠病学杂志(英文版);2014-07
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