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《Current Immunology》 2015-01
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Analysis of plasma MASP2 level and genetic polymorphisms of MASP2 in 119 Han Chinese

XU Xiao-dong;WANG Xiao-fang;XU Jing-fang;HUA Chun-zhen;The Affiliated Hospital of Hangzhou Normal University,School of Medicine;Children's Hospital of Zhejiang University,School of Medicine;  
To investigate the plasma levels and genetic polymorphisms of mannose-binding lectin-associated serine protease2(MASP2)in Han Chinese,plasma samples from 119 Han Chinese attending routine healthy examination were collected,and the levels of MASP2 were tested by enzyme-linked immunosorbent assay.In addition,polymorphisms of exon 3and 4of the MASP2 gene were analyzed by DNA sequencing.Our results showed that the plasma MASP2 levels of Han Chinese ranged from 0.0ng/ml to 1759.9ng/ml,with the median 226.5ng/ml.The plasma MASP2 levels in the children(median,627.4ng/ml)were significantly higher than that in the adults(median,109.3ng/ml,Z=-7.794,P=0.000).Sequence analysis showed that the variant allele frequencies at rs2273343 sites in exon 4of MASP2 gene was 0.033,and there was no polymorphism and mutation between +11sites in exon 1to+681sites in exon 3and+1710sites to+1814sites in exon 4.In conclusion,plasma MASP2 levels in children are is higher than adults as mutation in single nucleotide polymorphisms in MASP2 gene is rarely seen except for rs2273343 sites in exon 4.
【Fund】: 浙江省医药卫生科技计划项目(2011KYA128);; 杭州市科技计划项目(20130633B15);; 浙江省大学生科技创新活动计划项目(2014R421051)
【CateGory Index】: R446.6
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