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《Current Immunology》 2015-01
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Effect of recombinant human erythropoietin on chronical hyperoxia-induced bronchopulmonary dysplasia

GENG Lin-lin;LU -Wei;Department of Pediatrics ,Third Hospital of Shanghai jiao tong university;  
To investigate effect of recombinant human erythropoietin(rhEPO)as angiogenesis—like factor,on chronic lung disease exposed to hyperoxia in newborn rats.Ninty six Wistar newborn rats were randomly divided into four groups with 1hafter birth:room air-exposed control group,room air-exposed rhEPO treated group,hyperoxia-exposed group,hyperoxia-exposed rhEPO treated group.The last two groups were exposed to oxygen,FiO2=850mL/L,room air-exposed rhEPO treated and hyperoxia-exposed rhEPO treated group received rhEPO 2400IU/kg subcutaneously at birth,before thirty minutes exposed to oxygen and 2days after birth.The isodose of 9g/Lsaline were given in the same way in room air-exposed controls and hyperoxia-exposed pups.Rats from per group were sacrificed on 3,7and 10 d.Lung histology was observed under microscope,CD3 land vascular endothelial growth factor(VEGF)expression were measured by immunohistochemistry.Results in hyperoxia+rhEPO group,expression of lung CD31 and VEGF in newborn rats were significantly higher than those in hyperoxia group,increased on 3dand reached peak10 d.Conclusion rhEPO(2400IU/kg)have protective effect and accelerate growth on pulmonary vessels in hyperoxia-induced BPD of newborn rats.
【Fund】: 上海市卫生局科研基金(20114139)
【CateGory Index】: R722.6
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