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《Current Immunology》 2015-06
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Purine nucleoside phosphorylase is associated with the pathogenesis of systemic lupus erythematosus

QIAN Jie;DAI Min;ZHOU Shi-yu;HAN Xiao;WAN Nian-hong;MA Jian-yang;SHEN Nan;LI Ning-li;Basic Medicine Faculty of Shanghai JiaoTong University;Shanghai Institute of Rheumatology,Shanghai Renji Hospital,Shanghai Jiaotong University School of Medicine;Institute of Health Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine;Shanghai Zhabei Center Hospital;  
Abnormal degradation of purine mediated by urine nucleoside phosphorylase(PNP)affects the synthesis of DNA.In this study,we investigated the correlation between PNP expression and the activity of systemic lupus erythematosus(SLE).We measured the mRNA levels of PNP in PBMC from 42 patients with SLE and 48 healthy controls,as well as kidney biopsies from 12 patients with SLE lupus nephritis and 10 control patients with kidney cancer.The association of PNP expression with the manifestations of lupus was then analyzed.Since type I IFN signaling is crucial for the development of lupus,we also analyzed the correlation between PNP expression and IFN scores.We found that the levels of PNP in both PBMC and kidney tissues from lupus patients were significantly reduced compared with disease controls.In particular,PNP expression is negatively correlated with IFN scores,suggesting that PNP might be involved in regulating type I IFN signaling.Taken together,our data demonstrated that the expression of PNP is dysregulated in lupus patients.These findings indicate that PNP might play a role in the pathogenesis of SLE.
【Fund】: 国家重点基础研究发展计划(973计划:2014CB541902);; 国家自然科学基金重点项目(81230072);; 基金委创新团队(81421001)
【CateGory Index】: R593.241
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