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《Current Immunology》 2015-06
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Effect of chronic inflammation status on the peripheral memory CD8~+T cells in ankylosing spondilitis

JIN Yan-hua;YE Ling-ying;ZHANG Li-bin;XU Hu-ji;Department of Rheumatology,Changzheng Hospital,School of medicine,The Second Military Medical University;  
Ankylosing spondylitis patients are prone to infection,which may relate to altered subsets and function of peripheral CD8~+memory T cells..In this study,we set to explore the effect of autoimmune inflammation on memory T cells,we analyzed the percentage of total CD8~+memory T cell and subsets profile,cytokine IL-2and IFN-γsecreting memory cells,and percentage of antigen-specific memory T cells in peripheral blood mononuclear cells of ankylosing spondylitis(AS)patients.The proportion of CD8~+memory T cells,functional CD8~+memory T cells and antigen-specific memory T cell were detected by flow cytometry.Compared with the healthy controls,all AS patients showed no significant difference in the proportion of total CD8~+memory T cells.However,the proportion of CD8~+central memory T cells was increased and the proportion of CD8~+effector memory T cell was decreased in the patients compared with the healthy controls.Further functional study showed that IFN-γsecretion by CD8~+memory T cell were declined in all patients compare to the healthy controls(P0.05),while IL-2secretion level showed no significant difference.Furthermore,percentage of antigen-specific memory T cell in the patients was increased compared to that in the normal controls(P0.05).The capability of IFN-γsecretion of CD8~+memory T cells was declined,and antigen-specific memory T cells was increased in the patients,which might related to the high incidence of infection in patients.
【Fund】: 第二军医大学附属长征医院博士创新基金
【CateGory Index】: R593.23
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wen Huifang;Department of Rehabilitation,Jincheng Coal Group General Hospital;;Clinical value of HLA-B27 antigen expression in the diagnosis of ankylosing spondylitis[J];中国基层医药;2016-18
【Co-references】
Chinese Journal Full-text Database 7 Hits
1 JIN Yan-hua;YE Ling-ying;ZHANG Li-bin;XU Hu-ji;Department of Rheumatology,Changzheng Hospital,School of medicine,The Second Military Medical University;;Effect of chronic inflammation status on the peripheral memory CD8~+T cells in ankylosing spondilitis[J];现代免疫学;2015-06
2 WANG Ping-jun;SUN Ling-di;MEI Chuan- zhong;The affiliated123 Hospital of PLA of Bengbu Medical College;;Application of PCR-SBT method in HLA-B27detection in AS patients[J];中国实验诊断学;2015-11
3 WANG Weiyuan;LI Junfang;LI Zhijun;Department of Rheumatology,Handan Central Hospital;Department of Rheumatology,The First Affiliated Hospital of Bengbu Medical College;;The value of TLR2 and TLR4 expression in peripheral blood monouclear cells in patients with ankylosing spondylitis[J];西部医学;2015-11
4 CAI Chun-shui;XIAO Ping;Department of Orthopedics,the First People’s Hospital of Foshan(Affiliated Foshan Hospital of Sun Yat-sen University);;Significance of Th and Tc subsets in peripheral blood from HLA-B27 positive ankylosing spondylitis patients[J];中国热带医学;2015-11
5 AI Jin-wei;LI De-sheng;LIU Yu;LIN Hong-ming;WANG Qian;PEI Bin;Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine;Department of Orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine;;Diagnostic Value of HLA-B27 for Ankylosing Spondylitis in China: A Meta-analysis[J];中国循证医学杂志;2015-09
6 LU Zhan-zhong;LI Zhen-bin;HUI Nai-ling;ZHU Jian-jun;LIU Yan-qing;YANG Jing;ZHANG Xiao-gang;WANG Zhi-qiang;MA Xu;Department of Rheumatology and Immunology,Bethune International Peace Hospital of PLA;Graduate School,Hebei Medical University;;Short-term Curative Effect of Panax Notoginsenosidum in Treatment of Ankylosing Spondylitis[J];解放军医药杂志;2015-01
7 WEI Rongmei DONG Liping WU Honghui XU Yanqun Department of Clinical Laboratory,Guangzhou Orthopedic Hospital,Guangdong Province,Guangzhou 510045,China;Diagnostic value of ESR, HLA - B27 genes, CRP for ankylosing spondylitis[J];中国医药导报;2013-14
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