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《Current Immunology》 2015-06
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Meta-analysis of the association of ankylosing spondilytis with IL-23R gene

XU Zhong-yu;FANG Guang-cui;CHEN Kai-jie;XIE Zhi-xiong;Department of Clinical Laboratory,the 175th Hospital of PLA/Affiliated Dongnan Hospital of Xiamen University;Department of Pharmacy,the 175th Hospital of PLA/Affiliated Dongnan Hospital of Xiamen University;  
This study aims to validate the association of ankylosing spondylitis(AS)with IL-23 Rgene polymorphism with Meta-analysis in Chinese people.Relevant studies on AS and IL-23 Rwere retrieved from PubMed,CNKI,FMJS and Wanfang databases and a Meta-analysis was conducted,The statistical analysis was carried out with Reveman 5.2software.A total of 9literatures were enrolled.Our analysis suggested that no significant differences were found in allele frequency of rs10889677、rs1004819、rs11209032and rs1343151 between the cases and controls by random effects model.And rs10489629 may be the protective SNPs.We conclude that there is no association between the IL-23 Rgene polymorphisms tested in this study and the susceptibility to AS in this Chinese sample,and further exploration is needed to search for other possible susceptibility genes.
【CateGory Index】: R593.23
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