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《Current Immunology》 2015-06
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Association of vitamin D receptor gene Tru9 restriction length polymorphisms with ankylosing spondylitis of Han nationality in Zunyi

XIAO Dai-Min;ZHANG Zhi-Min;ZHANG Yang;LI Long-Feng;Clinical Laboratory,Affiliated Hospital of Zunyi Medical College;Cell Biology and Genetics Department,Zunyi Medical College;  
Fifty patients with ankylosing spondylitis and 69 normal individuals from Zunyi area,all Han nationality,were enrolled in this study.Peripheral blood samples were collected,and subjected to PCR-RFLP analysis for the polymorphism of Tru9,the 8thintron of vitamin D receptor(VDR)gene.The distribution of the genotypes and allele frequencies of Tru9 in the AS patients group and case-control group were calculated and association with the disease was analyzed.The allele frequencies of(the VDR gene)Tru9I were:T 92.0%,t 8.0%in the patients group,versus T 76.8%,t 23.2%in the normal group.The difference in genotype frequencies between the two groups was statistically significant(p=0.002).Therefore,the PCRRFLP of VDR gene Tru9 are associated with AS in Han nationality from Zunyi area.
【Fund】: 贵州省卫生厅项目(D349)
【CateGory Index】: R593.23
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