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《Current Immunology》 2015-06
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Different level expression of Ki67 and its clinical significance in the treatment of breast cancer

LIN Xiu-xin;YU Geng-sheng;DENG Wen-jing;ZHOU Ying;LI Chun-ming;Jiangmen Central Hospital;  
This study aimed to explore the significance of Ki67 labeling index in the treatment and prognosis of breast cancer by analyzing the correlation between Ki67 level and clinical pathological characteristics and its change of level after neoadjuvant chemotherapy in patients who had been subjected to surgical operation.Immunohistochemical method(SP)was adapted to determine the positive rate of Ki67 in the cancer tissues from 336 cases of patients with breast cancer who admitted to our hospital since 2012.In addition,90 cases were examined before and after neoadjuvant chemotherapy.The results showed that Ki67 positive ratio was 67.5%(166/246),and the positive rate was positively correlated with tumor size,lymph node metastasis,histological grading and human epidermal growth factor receptor-2(P0.05 or P0.01)but not correlated with TNM stage.In contrast,Ki67 positivity was negatively correlated with age,estrogen receptor and progesterone receptor(P0.01).Ki67 level was decreased after chemotherapy and was significantly associated with the efficacy of treatment(P0.01),the more efficient of the therapy,the lower the Ki67 level.Altogether,these findings indicate that there is a close correlation between the positive expression of Ki67 and the occurrence and development of breast cancer,suggesting that Ki67 may participate the whole course of carcinogenesis of breast cancer.The test of Ki67 might be valuable for early diagnosis,treatment and prognosis of breast cancer;however,it should not be taken as an absolute index for estimating the survival rate of patients with breast cancer.
【CateGory Index】: R737.9
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