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《Current Immunology》 2015-06
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Levels of serum follostatin-like-1 and progranulin in patients with polymyositis/dermatomyositis and relevant clinical significance

TIAN Pan;YU Lian;AN Hong-yu;HUANG Jian-qing;The First Affiliated Longyan Hospital of Fujian Medical University;  
This study aims to detect the levels of serum Follostatin-like-1(FSTLl)and Progranulin(PGRN),and to explore the relationship of FSTLl and PGRN to disease activity in patients with polymyositis/dermatomyositis(PM/DM).The levels of serum FSTLl and PGRN in 36 cases of PM/DM patients and 25 healthy controls were tested by using enzyme-linked immunosorbent assay(ELISA),and the differences between the patient group and the normal controls were analyzed by Mann.Whitney U-test,t-test,Pearson-test and Spearman-test.The serum levels of FSTL1/PGRN in the PM/DM group were significantly higher than those of the healthy controls,and the values of ESR and CRP were to some degree positively correlated with serum FSTL1/PGRN concentrations;and the FSTL1/PGRN levels of patients with pulmonary fibrosis increased obviously,and the total disease activity scores were positively correlated with serum FSTL1/PGRN concentrations;both the serum FSTLI/PGRN concentrations and disease activity scores significantly declined after treatment.The levels of FSTLl and PGRN were significantly increased in PM/DM patients,and were in parallel with disease activity score,suggesting that FSTLl and PGRN may reflect disease activity,so could be used as an evaluation indicator of PM/DM disease activity.
【CateGory Index】: R593.26
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