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《Chinese Journal of Biotechnology》 1993-01
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Kinetic Study and Modelling on L-arginine Fermentation

Gong Jianhua Ding Jiuyuan Huang Herong Chen Qi (Institute of Microbiology,Academia Sinica, Beijing 100080)  
The batch culture of the L-arginine fermentation by Coorynebaoterium crenatum L-arginine-producing mutant 971.1 was kineticly studied in the 2.6 L fermenter for the purpose as follows: (1) Kinetic classification of L-arginine fermentation by means of the comparison of the two-phases of specific growth rate; (2) Modelling of the L-arginine fermentation; (3) The discussion about the effects of the oxygen supply on the conversion rate of glucose to L-arginine, by comparison between the fractions of glucose-consumption for L-arginine formation, α_(?), and the ones of glucose consumption for cell growth, α_x, under the different oxygen transfer coefficients, k_La. As a result, the kinetic fermentative behaviour of the strain 971.1, which relates to the velocity and the effectiveness of the metabolism of the cell, in L-arginine-formation cultivation were mathematically analysied.
【Fund】: 国家自然科学基金
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