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《Chinese Journal of Biotechnology》 2001-05
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Purification of Vancomycin by Using Magnetic Affinity Technique

GUO Li\|An 1 \ ZHU Bao\|Quan\+2\ CHEN Dai\|Jie\+2 (Chemical Department,The Fourth Military Medical University,Xi'an 710032,China) (Shanghai Institute of Pharmaceutical Industry, Shanghai 200043,China)  
A new kind of magnetic affinity microspheres (MAMS),whose ligand is D\|Ala\|D\|Ala,was prepared using agarose as matrix.By using this new MAMS vancomycin was purified directly from crude fermentation liquor with only one step.The purity and the mass recovery of vancomycin measured by reverse\|phase HPLC were 97% and 87%,respectively.The characteristic of this method was simpler,faster,cheaper and more effective than that of currently used ones.
【Fund】: 国家自然科学基金(30 0 80 0 7);; 陕西省自然科学基金的资助 (99H0 9);; 高等学校骨干教师计划(2 0 0 0 6 5 6 6 )资助&&
【CateGory Index】: O658
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