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Bibliometric analysis of antibody-drug conjugates

XU Ying;ZHOU Jie;ZHOU Zhan;CHEN Shu-qing;Laboratory of Precision Medicine and Biotechnology Drug,College of Pharmaceutical Sciences,Zhejiang University;  
Objective To retrieve and analyze domestic and international literatures about antibody-drug conjugates,and understand the recent progress and current situation. Methods Pub Med,Web of Science and CNKI were searched to collect all the literatures connected with ADCs from the beginning to January,2016. Endnote X7 was used to sort out and summarize. The type of literature,published year,first author,research institution,published journal,cited frequency,research contents and patent situation were analyzed with bibliometric methods. Results A total of 645 literatures were included,among which 495 were foreign articles and 150 were Chinese articles. The literatures greatly increased after the 21 st century. The top one nation and journal which published the most articles were America and Clinical Cancer Research,respectively. Krop IE and Younes A published the most articles. Among them,the most frequently cited paper was cited up to 686 times. Selection of the targets,site-specific drug conjugation to antibodies and cytotoxic agents were frequently involved. Conclusion ADCs, which have made breakthrough progress, are the focus in the field of cancer research. However,there is still room for improvement,and we still need further exploration.
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