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《Shanghai Medical Journal》 1992-01
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ALTERATION IN PLASMA FIBRINOLYTIC ACTIVITY IN PATIENTS WITH VIRAL HEPATITIS

Wang Hong-li, et al. Ruijing Hospital, Shanghai Institute of Hematology Shanghai Second Medical University, Shanghai 200025  
Plasma concentrations of t-PA, PLGAg, PLGA, PL, FDPs, PAI and α_2-PI wers assessed in 70 normal subjects and 231 patients with various types of viral hepatitis, They were used as indicators of plasma fibrinolytic activity. In patients with viral hepatitis, the plasma levels of t-PA, PL and FDPs increased, but the plasma levels of PAI, PLG and α_2-PI decreased, suggesting an augmentation of plasma fibrinolytic activity. This may provide an important theoretic basis of hemorrhage in these patients. Determination of plasma levels of CRM~+ PLG and FDPs may be a simple and practical method in the evaluation of plasma fibrinolytic activity in patients with viral hepatitis.
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