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《Shanghai Medical Journal》 2004-01
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Relevance of serum leptin level and bone mineral density in postmenopausal women

ZHAO Hongyan, LIU Jianmin, NING Guang, et al. Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China  
Objective To investigate the relevance of serum leptin level and bone mineral density(BMD) in postmenopausal women. Methods 140 healthy postmenopausal women were enrolled in this study. Body mass index(BMI), waist hip ratio(WHR), fat mass(FM), Fat%, fasting serum leptin and BMD were all individually measured.Results Serum leptin level was strongly correlated with body weight, BMI, WHR, FM and Fat%( P 0.01 ). Both serum leptin and Fat% were positively correlated with BMD of lumbar spine (L 2~4 ) and femoral neck(FN)( P 0.01) . After adjustment for age, weight and Fat%, the relevance of serum leptin and BMD of L 2~4 remained statistically significant( P 0.05). On the other hand, the significant relevance of Fat% and BMD of L 2~4 or FN disappeared after adjustment for age and weight. Multipule regression analysis revealed that serum leptin and age were the determinants of L 2~4 BMD( R 2=0.174, P =0.000), body weight and age were the determinants of FN BMD( R 2=0.264, P =0.000). Conclusions Serum leptin may be a significant and independent predictor of L 2~4 BMD in postmenopausal women and this positive effect was independent of age, body weight and Fat%.
【CateGory Index】: R58
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