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《Shanghai Medical Journal》 2004-01
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Relevance of serum soluble E-selectin level and blood pressure in hypertensive patients

ZHANG Jianliang, QIN Yongwen, ZHENG Xing, et al. Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China  
Objective To explore the relevance of serum soluble E selectin (sE selectin) level and blood pressure, degree of obesity, blood glucose and serum lipid in hypertensives. Methods Serum sE selectin concentrations were measured by enzyme immunoassay. Systolic pressure (SBP), diastolic pressure (DBP), body mass index (BMI), fasting blood glucose, total cholesterol, triglyceride (TG) were determined in 95 uncomplicated patients with grade 1 hypertensives and 35 normotensives. The correlation between sE selectin and other parameters were analyzed.Results ① The level of sE selectin was significantly higher in hypertensives group [(42.5±15.3) μg/L] than that in normotensives group [(33.2±14.8) μg/L, P 0.01]. The difference of serum sE selectin concentrations between the two groups disappeared when BMI was corrected by analysis of covariance. ② Serum sE selectin concentrations [(40.0±15.7) μg/L] in both groups were positive significantly correlated with SBP 、DBP、BMI、TG( P 0.05 and 0.001). ③ If patients with overweight and underweight were excluded, the difference of serum sE selectin concentrations between the two groups were not significant,but were correlated with BMI ( P 0.05), and no longer related to blood pressure. Conclusion Serum sE selectin concentrations are not directly related to the blood pressure in uncomplicated grade 1 hypertensives and normotensives, but are actually in close relation with the degree of obesity.
【CateGory Index】: R544.1
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